Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

09 March 2021 : Original article  

Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage

Alvaro Arnau1BEF*, Adalberto Benito-Hernández1ABCDEFG, María Angeles Ramos-Barrón1BCDF, María Teresa García-Unzueta2BCDF, José Javier Gómez-Román3BCDF, José María Gómez-Ortega3BCDF, Marcos López-Hoyos4BCDFG, David San Segundo4BCDF, Juan Carlos Ruiz1BCDFG, Emilio Rodrigo1ABCDEFG

DOI: 10.12659/AOT.929491

Ann Transplant 2021; 26:e929491

Table 1 Main patient and transplant characteristics and variables related to both clinical and subclinical antibody-mediated rejection (AbMR) and T cell-mediated rejection (TCMR).

All patients (n=151)No AbMR (n=99)AbMR (n=52)pNo TCMR (n=115)TCMR (n=36)p
Recipient age (years)49.2±12.650.6±12.146.3±13.10.03950.5±12.045.3±14.00.032
Recipient gender (Male)61.6%63.6%57.7%0.47567.8%41.7%0.005
Donor age (years)49.9±14.149.7±13.350.3±15.70.79850.2±14.248.9±13.90.640
Life donor14.6%10.1%23.1%0.03210.4%27.8%0.010
ECD29.1%24.2%38.5%0.06831.3%22.2%0.295
DCD22.5%28.3%11.5%0.01922.6%22.2%0.961
Mismatches4.0±1.34.0±1.34.1±1.30.9394.0±1.44.1±1.10.846
CIT (hours)14.5±7.914.1±7.415.2±8.80.47215.1±7.712.4±8.20.073
SPK12.6%15.2%7.7%0.18912.2%13.9%0.787
Pretransplant DSA6.6%2.0%15.4%0.0027.8%2.8%0.288
Current cPRA (%)1.5±10.10.9±7.62.4±13.80.4052.0±11.60.0±0.00.073
Peak PRA >25%13.9%11.1%19.2%0.17116.6%5.6%0.097
DSA at biopsy27.2%10.1%59.6%<0.00121.7%44.4%0.008
Retransplant28.5%21.2%42.3%0.00630.4522.2%0.341
Prednisone dose (mg)4.5±3.24.7±3.54.3±2.50.4694.4±3.14.9±3.50.481
Tacrolimus blood level at biopsy (ng/ml)7.9±2.68.1±2.77.5±2.40.1767.9±2.58.0±2.80.853
Basiliximab induction17.2%18.2%15.4%0.66518.3%13.9%0.544
Thymoglobulin induction50.3%49.5%51.9%0.77753.9%38.9%0.116
DGF21.9%17.2%30.8%0.05524.3%13.9%0.185
Creatinine at biopsy (mg/dl)1.59±0.811.43±0.691.90±0.930.0011.50±0.701.89±1.040.010
eGFR at biopsy (ml/min/1.73 m)55±2461±2345±20<0.00158±2445±210.002
Proteinuria at biopsy (mg/day)940±1656606±11371579±22260.004835±16201275±17480.165
CXCL10/Cr at biopsy (ng/mmol)15.52±15.4312.52±14.2421.24±16.100.00113.82±15.0120.96±15.670.015
Logarithm of CXCL10/Cr at biopsy1.07±0.310.98±0.301.24±0.27<0.0011.01±0.311.23±0.28<0.001
CXCL10/Cr 3 tertile33.8%23.2%53.8%<0.00127.8%52.8%0.006
ECD – expanded criteria donor; DCD – donation after cardiac death; CIT – cold ischemia time; SPK – simultaneous pancreas and kidney transplant; DSA – donor-specific antibodies; PRA – panel-reactive antibodies; DGF – delayed graft function; eGFR – estimated glomerular filtration rate.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358