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09 March 2021: Original Paper

Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage

Alvaro Arnau 1BEF , Adalberto Benito-Hernández 1ABCDEFG , María Angeles Ramos-Barrón 1BCDF , María Teresa García-Unzueta 2BCDF , José Javier Gómez-Román 3BCDF , José María Gómez-Ortega 3BCDF , Marcos López-Hoyos 4BCDFG , David San Segundo 4BCDF , Juan Carlos Ruiz 1BCDFG , Emilio Rodrigo 1ABCDEFG*

DOI: 10.12659/AOT.929491

Ann Transplant 2021; 26:e929491

Table 1 Main patient and transplant characteristics and variables related to both clinical and subclinical antibody-mediated rejection (AbMR) and T cell-mediated rejection (TCMR).

All patients (n=151)No AbMR (n=99)AbMR (n=52)pNo TCMR (n=115)TCMR (n=36)p
Recipient age (years)49.2±12.650.6±12.146.3±13.10.03950.5±12.045.3±14.00.032
Recipient gender (Male)61.6%63.6%57.7%0.47567.8%41.7%0.005
Donor age (years)49.9±14.149.7±13.350.3±15.70.79850.2±14.248.9±13.90.640
Life donor14.6%10.1%23.1%0.03210.4%27.8%0.010
CIT (hours)14.5±7.914.1±7.415.2±8.80.47215.1±7.712.4±8.20.073
Pretransplant DSA6.6%2.0%15.4%0.0027.8%2.8%0.288
Current cPRA (%)1.5±10.10.9±7.62.4±13.80.4052.0±11.60.0±0.00.073
Peak PRA >25%13.9%11.1%19.2%0.17116.6%5.6%0.097
DSA at biopsy27.2%10.1%59.6%21.7%44.4%0.008
Prednisone dose (mg)4.5±3.24.7±3.54.3±2.50.4694.4±3.14.9±3.50.481
Tacrolimus blood level at biopsy (ng/ml)7.9±2.68.1±2.77.5±2.40.1767.9±2.58.0±2.80.853
Basiliximab induction17.2%18.2%15.4%0.66518.3%13.9%0.544
Thymoglobulin induction50.3%49.5%51.9%0.77753.9%38.9%0.116
Creatinine at biopsy (mg/dl)1.59±0.811.43±0.691.90±0.930.0011.50±0.701.89±1.040.010
eGFR at biopsy (ml/min/1.73 m)55±2461±2345±2058±2445±210.002
Proteinuria at biopsy (mg/day)940±1656606±11371579±22260.004835±16201275±17480.165
CXCL10/Cr at biopsy (ng/mmol)15.52±15.4312.52±14.2421.24±16.100.00113.82±15.0120.96±15.670.015
Logarithm of CXCL10/Cr at biopsy1.07±0.310.98±0.301.24±0.271.01±0.311.23±0.28
CXCL10/Cr 3 tertile33.8%23.2%53.8%27.8%52.8%0.006
ECD – expanded criteria donor; DCD – donation after cardiac death; CIT – cold ischemia time; SPK – simultaneous pancreas and kidney transplant; DSA – donor-specific antibodies; PRA – panel-reactive antibodies; DGF – delayed graft function; eGFR – estimated glomerular filtration rate.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358