09 March 2021>: Original Paper
Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage
Alvaro Arnau 1BEF , Adalberto Benito-Hernández 1ABCDEFG , María Angeles Ramos-Barrón 1BCDF , María Teresa García-Unzueta 2BCDF , José Javier Gómez-Román 3BCDF , José María Gómez-Ortega 3BCDF , Marcos López-Hoyos 4BCDFG , David San Segundo 4BCDF , Juan Carlos Ruiz 1BCDFG , Emilio Rodrigo 1ABCDEFG*DOI: 10.12659/AOT.929491
Ann Transplant 2021; 26:e929491
Table 3 Variables associated with the highest tertile of urinary CXCL10 excretion in surveillance biopsies.
1st and 2nd tertiles of CXCL10 (n=69) | 3rd tertile of CXCL10 (n=23) | p | |
---|---|---|---|
Recipient age (years) | 50.6±11.8 | 54.1±11.8 | 0.227 |
Recipient gender (Male) | 66.7% | 43.5% | 0.048 |
Donor age (years) | 50.2±12.6 | 53.9±13.3 | 0.227 |
Life donor | 11.6% | 8.7% | 0.699 |
ECD | 29.0% | 39.1% | 0.364 |
DCD | 24.6% | 30.4% | 0.593 |
Mismatches | 3.9±1.4 | 4.2±0.9 | 0.523 |
CIT | 13.2±7.8 | 18.3±7.1 | 0.006 |
SPK | 17.4% | 4.3% | 0.120 |
Pretransplant DSA | 5.8% | 8.7% | 0.626 |
Current cPRA | 1.8±11.9 | 1.2±5.8 | 0.828 |
DSA at biopsy | 13.0% | 39.1% | 0.006 |
Retransplant | 24.6% | 39.1% | 0.181 |
Prednisone dose | 4.2±2.2 | 3.8±2.5 | 0.463 |
Tacrolimus blood level at biopsy | 7.8±2.3 | 7.9±2.5 | 0.883 |
3–12 month mean tacrolimus levels | 8.6±1.1 | 8.7±1.1 | 0.711 |
3–12 month CV tacrolimus levels | 23.5±8.9 | 26.6±6.9 | 0.133 |
%Time under 6 | 6.1±10.0 | 6.6±8.3 | 0.846 |
%Time under 6 >10% | 23.2% | 30.4% | 0.487 |
Basiliximab Induction | 17.4% | 21.7% | 0.642 |
Thymoglobulin Induction | 52.2% | 52.2% | 1.000 |
DGF | 17.4% | 30.4% | 0.181 |
Creatinine at biopsy (mg/dl) | 1.27±0.41 | 1.56±0.66 | 0.013 |
eGFR at biopsy (ml/min/1.73 m) | 65.9±21.9 | 48.7±18.5 | 0.001 |
Proteinuria at biopsy (mg/day) | 481.7±815.2 | 803.2±1511.9 | 0.198 |
Urinary Leukocytes | 4.6±14.8 | 21.7±33.6 | 0.026 |
BK nephropathy | 1.4% | 4.3% | 0.409 |
ECD – expanded criteria donor; DCD – donation after cardiac death; CIT – cold ischemia time; SPK – simultaneous pancreas and kidney transplant; DSA – donor-specific antibodies; PRA – panel-reactive antibodies; DGF – delayed graft function; eGFR – estimated glomerular filtration rate. |