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09 March 2021: Original Paper

Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage

Alvaro Arnau 1BEF , Adalberto Benito-Hernández 1ABCDEFG , María Angeles Ramos-Barrón 1BCDF , María Teresa García-Unzueta 2BCDF , José Javier Gómez-Román 3BCDF , José María Gómez-Ortega 3BCDF , Marcos López-Hoyos 4BCDFG , David San Segundo 4BCDF , Juan Carlos Ruiz 1BCDFG , Emilio Rodrigo 1ABCDEFG*

DOI: 10.12659/AOT.929491

Ann Transplant 2021; 26:e929491

Table 3 Variables associated with the highest tertile of urinary CXCL10 excretion in surveillance biopsies.

1st and 2nd tertiles of CXCL10 (n=69)3rd tertile of CXCL10 (n=23)p
Recipient age (years)50.6±11.854.1±11.80.227
Recipient gender (Male)66.7%43.5%0.048
Donor age (years)50.2±12.653.9±13.30.227
Life donor11.6%8.7%0.699
Pretransplant DSA5.8%8.7%0.626
Current cPRA1.8±11.91.2±5.80.828
DSA at biopsy13.0%39.1%0.006
Prednisone dose4.2±2.23.8±2.50.463
Tacrolimus blood level at biopsy7.8±2.37.9±2.50.883
3–12 month mean tacrolimus levels8.6±1.18.7±1.10.711
3–12 month CV tacrolimus levels23.5±8.926.6±6.90.133
%Time under 66.1±10.06.6±8.30.846
%Time under 6 >10%23.2%30.4%0.487
Basiliximab Induction17.4%21.7%0.642
Thymoglobulin Induction52.2%52.2%1.000
Creatinine at biopsy (mg/dl)1.27±0.411.56±0.660.013
eGFR at biopsy (ml/min/1.73 m)65.9±21.948.7±18.50.001
Proteinuria at biopsy (mg/day)481.7±815.2803.2±1511.90.198
Urinary Leukocytes4.6±14.821.7±33.60.026
BK nephropathy1.4%4.3%0.409
ECD – expanded criteria donor; DCD – donation after cardiac death; CIT – cold ischemia time; SPK – simultaneous pancreas and kidney transplant; DSA – donor-specific antibodies; PRA – panel-reactive antibodies; DGF – delayed graft function; eGFR – estimated glomerular filtration rate.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358