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09 March 2021: Original Paper

Urinary C-X-C Motif Chemokine 10 Is Related to Acute Graft Lesions Secondary to T Cell- and Antibody-Mediated Damage

Alvaro Arnau 1BEF , Adalberto Benito-Hernández 1ABCDEFG , María Angeles Ramos-Barrón 1BCDF , María Teresa García-Unzueta 2BCDF , José Javier Gómez-Román 3BCDF , José María Gómez-Ortega 3BCDF , Marcos López-Hoyos 4BCDFG , David San Segundo 4BCDF , Juan Carlos Ruiz 1BCDFG , Emilio Rodrigo 1ABCDEFG*

DOI: 10.12659/AOT.929491

Ann Transplant 2021; 26:e929491

Table 4 Variables related to subclinical antibody-mediated rejection (AbMR) and T cell-mediated rejection (TCMR).

No AbMR (n=69)AbMR (n=23)pNo TCMR (n=77)TCMR (n=15)p
Recipient age (years)52.1±11.949.8±11.70.42951.3±12.152.6±10.70.694
Recipient gender (Male)63.8%52.2%0.34263.6%46.7%0.218
Donor age (years)49.7±12.955.2±11.90.07350.8±12.952.6±12.60.625
Life donor7.2%21.7%0.0539.1%20.0%0.214
CIT (hours)14.3±7.415.0±9.50.74014.8±7.912.9±7.90.397
Pretransplant DSA0.0%26.1%6.5%6.7%0.980
Current PRA (%)0.4±3.35.4±20.60.2581.9±11.70.0±0.00.520
Peak PRA >25%10.1%26.1%0.05715.6%6.7%0.364
DSA at biopsy5.8%60.9%15.6%40.0%0.029
Prednisone dose (mg)3.9±2.44.8±1.70.0494.2±2.33.8±1.90.613
Tacrolimus blood level at biopsy (ng/ml)7.9±2.37.7±2.30.8117.8±2.37.6±2.60.613
Basiliximab induction18.8%17.4%0.87718.2%20.0%0.868
Thymoglobulin induction47.8%65.2%0.14854.5%40.0%0.302
Creatinine at biopsy (mg/dl)1.24±0.431.65±0.570.0041.29±0.451.59±0.660.036
eGFR at biopsy (ml/min/1.73 m)66.3±21.147.4±20.164±2249±19.20.015
Proteinuria at biopsy (mg/day)579±1167510±4510.785462±7431071±19010.241
CXCL10/Cr at biopsy (ng/mmol)11.92±16.0818.26±9.050.07612.4±15.519.1±9.60.111
Logarithm of CXCL10/Cr at biopsy0.93±0.301.21±0.220.95±0.301.22±0.250.002
CXCL10/Cr 3 tertile15.9%52.2%0.00119.5%53.3%0.006
ECD – expanded criteria donor; DCD – donation after cardiac death; CIT – cold ischemia time; SPK – simultaneous pancreas and kidney transplant; DSA – donor-specific antibodies; PRA – panel-reactive antibodies; DGF – delayed graft function; eGFR – estimated glomerular filtration rate.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358