18 May 2021 : Original article
Diagnostic Dilemma and Treatment Outcome in Acute Liver Failure Due to Wilson’s Disease
Rafał Stankiewicz1ABCDEF*, Waldemar Patkowski1DG, Krzysztof Zieniewicz1ADGDOI: 10.12659/AOT.930146
Ann Transplant 2021; 26:e930146
Table 1 Clinical and laboratory data of the study cohort.
| Variables | ||
|---|---|---|
| Age (mean, range) | 24.9 (18–45) | |
| Sex (F/M) | 17/3 | |
| Ascites | 18 (90.0%) | |
| Grade of encephalopathy | ||
| I/II | 5 (25.0%) | |
| III/IV | 15 (75.0%) | |
| Hypoglycemia | 2 (10.0%) | |
| MELD | 36.05±8.4 | 22–51 |
| Total bilirubin (mg/dL) | 35.31±14.25 | 6.4–53.4 |
| WBC (10/L) | 14.57±10.42 | 2.11–44.63 |
| AST (IU/L) | 240±210 | 94–1032 |
| ALT (IU/L) | 134±300 | 11–1385 |
| ALP (mg/dL) | 100±105 | 12–479 |
| INR | 4.12±2.16 | 2.04–10.0 |
| Prothrombin index (%) | 31.45±10.57 | 10–50 |
| Prothrombin time (s.) | 45.42±23.41 | 25.1–120 |
| Albumin (mg/dL) | 2.73±0.58 | 2.2–4.3 |
| Urea (mg/dL) | 58.0±41.46 | 13–180 |
| Serum creatinine (mg/dL) | 1.47±0.86 | 0.27–3.75 |
| Serum ammonia (μg/dL) | 151.55±93.29 | 43–381 |
| ALP/TB | 4.91±7.05 | 0.29–24.53 |
| AST/ALT | 3.93±3.37 | 0.75–16.45 |
| ALP – alkaline phosphatase elevation; ALT – alanine aminotransferase; AST – aspartate aminotransferase; INR – international normalized ratio; MELD – model for end-stage liver disease; SD – standard deviation; TB – total bilirubin; WBC – white blood cell. | ||