Diagnostic Dilemma and Treatment Outcome in Acute Liver Failure Due to Wilson’s Disease

18 May 2021: Original Paper

Rafał Stankiewicz ^ABCDEF* , Waldemar Patkowski ^DG , Krzysztof Zieniewicz ^ADG

DOI: 10.12659/AOT.930146

Ann Transplant 2021; 26:e930146

Table 1 Clinical and laboratory data of the study cohort.

Variables
Age (mean, range)	24.9 (18–45)

Sex (F/M)		17/3



Ascites	18 (90.0%)

Grade of encephalopathy
I/II	5 (25.0%)
III/IV	15 (75.0%)

Hypoglycemia		2 (10.0%)



MELD	36.05±8.4	22–51

Total bilirubin (mg/dL)	35.31±14.25	6.4–53.4

WBC (10/L)	14.57±10.42	2.11–44.63

AST (IU/L)	240±210	94–1032

ALT (IU/L)	134±300	11–1385

ALP (mg/dL)	100±105	12–479

INR	4.12±2.16	2.04–10.0

Prothrombin index (%)	31.45±10.57	10–50

Prothrombin time (s.)	45.42±23.41	25.1–120

Albumin (mg/dL)	2.73±0.58	2.2–4.3

Urea (mg/dL)	58.0±41.46	13–180

Serum creatinine (mg/dL)	1.47±0.86	0.27–3.75

Serum ammonia (μg/dL)	151.55±93.29	43–381

ALP/TB	4.91±7.05	0.29–24.53

AST/ALT	3.93±3.37	0.75–16.45
ALP – alkaline phosphatase elevation; ALT – alanine aminotransferase; AST – aspartate aminotransferase; INR – international normalized ratio; MELD – model for end-stage liver disease; SD – standard deviation; TB – total bilirubin; WBC – white blood cell.