Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions

Mehmet Tanrısev; Tülay Ayna Kılıçaslan; Hülya Çolak; Sibel Ersan; Banu Yılmaz; Alper Alp; Cem Tuğmen; Bahar Engin Sevgili

doi:10.12659/AOT.932434

17 September 2021 : Original article

Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions

Mehmet Tanrısev^1ABCDEF*, Tülay Ayna Kılıçaslan^2CD, Hülya Çolak^1BFG, Sibel Ersan^1BD, Banu Yılmaz^1BFG, Alper Alp^3B, Cem Tuğmen^4BC, Bahar Engin Sevgili

^5E

DOI: 10.12659/AOT.932434

Ann Transplant 2021; 26:e932434

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Table 1 Comparing demographic and comorbidity variables between groups.

Variables	mTOR group (n=37) mean±SD	CNI group (n=52) mean±SD	p
Age (year)	45.2±12.5	46.4±12.1	0.500
Transplant year	11.2±4.5	9.1±3.9
Transplant number	1.03±0.1	1.02±0.1	0.800
Mismatch	3.27±0.6	3.56±0.6

Sex (F/M)	19/18 (51.4/48.6)	21/31 (40.6/59.4)	0.300
Presence of DM	8 (21.6)	2 (3.8)
Presence of HT	17 (45.9)	31 (59.6)	0.200
Presence of CVD	2 (5.4)	1 (1.9)	0.568
Post-transplant BKVN	4 (10)	0 (0)
Post-transplant AR	4 (10.8)	7 (13.5)	0.700
Post-transplant malignancy	3 (8.1)	1 (1.9)	0.300
Delayed graft function	4 (10.8)	10 (19.2)	0.282
Cadaveric donor	15 (40.5)	22 (42.3)	0.867
Live donor	22 (59.5)	30 (57.7)	0.867
Induction therapy	29 (78.4)	42 (80.8)	0.781
Used ATG	8 (21.6)	21 (40.4)	0.236
Used IL-2 antagonist	21 (56.8)	21 (40.4)	0.693
Independent t test was used for comparing age parameter. Pearson’s or Fisher’s exact chi-square tests were used for categorical data. P

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Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions

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