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07 September 2021: Original Paper

Sofosbuvir/Velpatasvir Prophylaxis for 12 Weeks in Hepatitis C Virus (HCV)-Negative Recipients Receiving Kidney Transplantation from HCV-Positive Donors

Ruoyang Chen BCEF* , Dawei Li BCDFG* , Ming Zhang AC , Xiaodong Yuan ADEF*

DOI: 10.12659/AOT.933313

Ann Transplant 2021; 26:e933313

Table 1 Demographic and clinical characteristics of recipient and donor.

Recipient characteristics (n=26)
Median age (IQR), years42 (20~73)
Male, n (%)19 (73.1%)
Median body mass index, kg/m23.295 (17.03~33.66)
Cirrhosis, n (%)0
ALT level (U/L)10.5 (3~70)
Serum creatinine level (μmol/L)894 (373~1705)
eGFR (mL/min)7.715 (4~20.77)
Primary cause of renal failure (n=26)
 IgA nephropathy4
 Unknown cause15
History of diabetes (n)2
HBsAg-positive (n)2
HCV Ab-positive (n)0
Median time on dialysis before transplantation (d)330 (0~4340)
Median time on waitlist before transplantation (d)198 (29~865)
Induction immunosuppression, (n=26)
Maintenance immunosuppression, (n=26)
Male, n (%)14 (93.3%)
Cause of death, (n)
Median terminal serum creatine (μmol/L)84.5 (24~194.5)
ALT – alanine aminotransferase; eGFR – estimated glomerular filtration rate; PKD – polycystic kidney disease; FSGS – focal segmental glomerulosclerosis; DN – diabetic nephropathy; HN – hypertensive nephrosclerosis; rATG – rabbit anti-human thymocyte; FK – tacrolimus; MPA – mycophenolic acid; DBD – donation after brain death; DCD – donation after cardiac death.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358