Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

Takahiro Yokose; Masashi Takeuchi; Hideaki Obara; Masahiro Shinoda; Hirofumi Kawakubo; Minoru Kitago; Hiroshi Yagi; Yuta Abe; Yohei Yamada; Kentaro Matsubara; Go Oshima; Shutaro Hori; Takumi Fujimura; Ryo Takemura; Ryota Ishii; Tatsuo Kuroda; Yuko Kitagawa

doi:10.12659/AOT.933774

19 November 2021 : Original article

Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

Takahiro Yokose^1ABCDEF, Masashi Takeuchi^1ABCDEF, Hideaki Obara^1ACDEFG*, Masahiro Shinoda^2ADF, Hirofumi Kawakubo^1ADF, Minoru Kitago

^1BCD, Hiroshi Yagi^1BCD, Yuta Abe^1BCD, Yohei Yamada^1BCD, Kentaro Matsubara^1BCD, Go Oshima^1BCD, Shutaro Hori^1BCD, Takumi Fujimura^1BCD, Ryo Takemura^3CD, Ryota Ishii^3CD, Tatsuo Kuroda^1A, Yuko Kitagawa^1AG

DOI: 10.12659/AOT.933774

Ann Transplant 2021; 26:e933774

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Table 5 Comparison of patient characteristics between high and low preoperative levels of presepsin.

Variables, (%)	Preoperative high (n=5)	Preoperative low (n=8)	p
Recipient age, years^*	42 (38–55)	46 (41–51)	0.833
Body mass index, kg/m^*	19.8 (18.3–26.8)	21.2 (19.4–22.9)	0.943
Sex, Male / Female	1 (20.0) / 4 (80.0)	3 (37.5) / 5 (62.5)	0.506
ASA-PS, 2 / 3 / 4	0 / 2 (40.0) / 3 (60.0)	2 (25.0) / 5 (62.5) / 1 (12.5)	0.150
ECOG-PS, 0–1 / 2–3	0 / 5 (100)	5 (62.5) / 3 (37.5)	0.024
Primary disease
Alcohol-related liver disease	0	4 (50.0)
Primary biliary cholangitis	3 (60.0)	0
Primary sclerosing cholangitis6	2 (40.0)	0
Autoimmune hepatitis	0	2 (25.0)
Hepatopulmonary syndrome	0	1 (12.5)
Unknown	0	1 (12.5)
Child-Pugh score^*	12 (11–13)	12 (10–13)	0.622
MELD score^*	33 (32–36)	21 (16–26)	0.011
Creatinine clearance^*	35.7 (32.1–98.5)	74.6 (64.7–96.0)	0.284
Donor type
Living / Deceased	1 (20.0) / 4 (80.0)	6 (75.0) / 2 (25.0)	0.053
Donor Age, years^*	44 (42–52)	44 (29–49)	0.833
ABO blood type
Identical / Compatible / Incompatible	3 (60.0) / 2 (40.0) / 0	6 (75.0) / 0 / 2 (25.0)	0.224
Intraoperative bleeding, ml ^*	5390 (3295–5583)	2273 (984–3467)	0.284
Operation time, min^*	708 (600–774)	876 (737–917)	0.354
Bile duct reconstruction
Hepaticocholedochostomy / Hepaticojejunostomy	3 (60.0) / 2 (40.0)	8 (100.0) / 0	0.052
Postoperative acute kidney injury	4 (80.0)	5 (62.5)	0.506
Postoperative continuous renal replacement therapy	2 (40.0)	2 (25.0)	0.569
^* Median (25–75 percentiles). ASA – American Society of Anesthesiologists; PS – performance status; ECOG – Eastern Cooperative Oncology Group; MELD – model for end-stage liver disease.

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Diagnostic Utility of Presepsin in Infections After Liver Transplantation: A Preliminary Study

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