18 February 2022>: Original Paper
Impact on Waitlist Outcomes from Changes in the Medical Eligibility of Candidates for Simultaneous Liver-Kidney Transplantation Following Implementation of the 2017 Organ Procurement and Transplantation Network/United Network for Organ Sharing Policy in the United States
Shingo Shimada 1ADEF , Toshihiro Kitajima 1BCE , Yukiko Suzuki 1BD , Yasutaka Kuno 1BD , Tayseer Shamaa 1BC , Tommy Ivanics 1BCE , Kelly Collins 1DE , Michael Rizzari 1BD , Atsushi Yoshida 1BD , Marwan Abouljoud 1BD , Dilip Moonka 2BD , Shunji Nagai 1ACE*DOI: 10.12659/AOT.934850
Ann Transplant 2022; 27:e934850
Table 6 Risk factors of 1-year graft loss and mortality after simultaneous liver-kidney transplantation.
Factors | Graft loss | Mortality | ||||
---|---|---|---|---|---|---|
aHR* | 95% CI | P value | aHR* | 95% CI | P value | |
Donor age 40–59y (ref. | 1.69 | 1.20–2.38 | 0.002 | 1.74 | 1.21–2.50 | 0.002 |
Donor age ≥60y (ref. | 3.32 | 1.72–6.44 | 3.44 | 1.76–6.71 | ||
Mechanically ventilated | 1.78 | 1.13–2.79 | 0.01 | 1.75 | 1.09–2.81 | 0.02 |
Serum sodium | 1.44 | 1.03–2.02 | 0.03 | 1.57 | 1.10–2.22 | 0.01 |
Serum sodium ≥145 mEq/L (ref. 135≤, | 2.70 | 1.19–6.11 | 0.01 | 2.28 | 0.88–5.91 | 0.08 |
After the 2017 policy (ref. Before the 2017 policy) | 1.57 | 1.11–2.22 | 0.01 | 1.64 | 1.14–2.35 | 0.007 |
* Hazards were adjusted by a multivariable Cox regression model for the following variables present at the time of SLK: recipient age, recipient race, encephalopathy, ascites, mechanical ventilation, dialysis, recipient diabetes, recipient body mass index (BMI), model for end-stage liver disease (MELD) score, Karnofsky score, serum sodium, cold ischemia time, donor age, donor BMI, donor race, donation after circulatory death donor, registered era, and United Network for Organ Sharing (UNOS) regions. aHR – adjusted hazard ratio; CI – confidence interval; SLK – simultaneous liver-kidney transplantation. |