12 July 2022: Original Paper
Effect of Nephrectomy After Allograft Failure on Inflammation, Erythropoiesis, Donor-Specific Antibodies, and Outcome of Re-Transplantation
Panagiota Zgoura 1BC* , Adrian Doevelaar 1E , Benjamin Rohn 1F , Felix S. Seibert 1CD , Maximilian Seidel 1CD , Falko Markus Heinemann 2CD , Nina Pillokeit 3E , Richard Viebahn 3ABCD , Nina Babel 1BCD , Timm H. Westhoff 1ACDEDOI: 10.12659/AOT.935625
Ann Transplant 2022; 27:e935625
Table 1 Study population.
| Transplant in situ (n=49) | Tx-Nephrectomy (n=43) | P | |
|---|---|---|---|
| Age (years) | 56.3±18.4 | 54.0±11.3 | 0.23 |
| Time until transplant failure (months) | 125±24 | 24.5±34.7 | |
| Live donor transplantation (%) | 6 (12.3%) | 5 (11.6%) | 0.93 |
| CRP (mg/dl) | 0.82±0.24 | 1.12±0.31 | 0.21 |
| Donor specific antibodies (DSA) | 19 (38.8%) | 28 (65.1%) | |
| Hb (ml/min) | 11.57±0.35 | 11.83±0.26 | 0.46 |
| EPO (IE) | 6204±1077 | 4395±1809 | 0.10 |
| Eisen (mg/Week) | 31.46±12.3 | 47.91±16.45 | 0.18 |
| Ferritin (ug/l) | 387.6±75.12 | 475.9±88.25 | 0.25 |
| Dual immunosuppression | 18 (36.7%) | 0 (0.0%) | 0.99 |
| Mono immunosuppression | 16 (32.7%) | 0 (0.0%) | 0.99 |
| Diabetic nephropathy | 12 (24.5%) | 12 (27.9%) | 0.71 |
| Glomerulonephritis | 14 (28.6%) | 11 (25.6%) | 0.74 |
| Hereditary dysplasia/reflux | 6 (12.2%) | 6 (14.0%) | 0.80 |
| Polycystic kidney disease | 4 (8.2%) | 0 (0.0%) | 0.05 |
| Benign nephrosclerosis | 2 (4.1%) | 2 (4.7%) | 0.89 |
| Alport syndrome | 3 (6.1%) | 0 (0.0%) | 0.09 |
| Interstitiell nephritis | 1 (2.0%) | 2 (4.7%) | 0.48 |
| Other causes | 7 (14.3%) | 10 (23.3%) | 0.27 |
| 18 (43.0%) | 25 (58.1%) | 0.04 | |
| 12 (80.0%) | 3 (20.0%) | 0.11 | |
| 1.69±0.83 | 1.28±0.41 | 0.08 | |
| 46.71±14.0 | 50.6±8.9 | 0.36 | |
| Numeric data are presented as mean and standard deviation. Numeric data were tested for statistically significant differences using Mann-Whitney-U Test and Fisher’s exact test. P | |||