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10 May 2022: Original Paper

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

Bruno Roche 1BCDE , Artur Bauhofer 2ACDEF* , Miguel Ãngel Gomez Bravo 3BCDE , Georges Philippe Pageaux 4ABCDE , Fabien Zoulim 5BDE , Alejandra Otero 6BC , Martin Prieto 78BC , Carmen Baliellas 9BC , Didier Samuel 1ACDE

DOI: 10.12659/AOT.936162

Ann Transplant 2022; 27:e936162

Table 4 Characteristics of patients with HBV recurrence.

Patient no.Time to HBV recurrence [months]Determination of HBV recurrenceRisk factors before/at time of LTAntiviral treatment at time of HBV recurrenceHCC recurrence after LT
Clinical signsHBsAg [IU/mL]*HBV DNA [IU/mL]*Viral co-infectionHBsAg [IU/mL]HBeAg [IU/mL]HBV DNA [IU/mL]sc HBIg dose/ intervalAnti-HBs [IU/L]NUC
118.5None+NDNone+NDND500 IU/ biweekly108.2TDVYes
223.5None+NDHDV+NDND500 IU/ every 10 days22.6ETVNo
334.6Not docND12None2156ND20500 IU/ every 5 weeks167.9ETVNo
421.8Not doc+NDNone57NAND500 IU/ weekly100.1TDVYes
513.1Not doc28NDHDV8500NDND500 IU/ biweekly29ETVNo
615.0Not doc199NDHDVNANDND500 IU/ monthlyNAETVNo
713.2Not doc+NANone3159NDND500 IU/ every 3 weeksNATDVYes
* Values at time of first identification of HBV recurrence after LT.
ETV – entecavir; HBsAg – hepatitis B surface antigen; HBV – hepatitis B virus; HCC – hepatocellular carcinoma; HDV – hepatitis D virus; IU – international unit; LT – liver transplantation; NA – not available; ND – not detectable; Not doc – not documented; NUC – nucleos(t)ide analog; TDV – tenofovir.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358