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10 May 2022: Original Paper

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

Bruno Roche 1BCDE , Artur Bauhofer 2ACDEF* , Miguel Ãngel Gomez Bravo 3BCDE , Georges Philippe Pageaux 4ABCDE , Fabien Zoulim 5BDE , Alejandra Otero 6BC , Martin Prieto 78BC , Carmen Baliellas 9BC , Didier Samuel 1ACDE

DOI: 10.12659/AOT.936162

Ann Transplant 2022; 27:e936162

Table 6 HBV and HCC recurrence rates after LT under various prophylactic regimens.

Author, year [ref]Patients, N/n (total/HCC)Prophylactic treatmentMedian duration of follow up, (total/HCC) [months]HBV recurrence (based on HBsAg and/or HBV DNA) N (%)/ARHCC recurrence n (%)/ARComments
Fung et al, 2017 []21 242/97NUC only (entecavir)59/5136 (14.9)/3.03%13 (13.4)/3.15%Only patients with HBsAg clearance post LT included patients with re-transplantation and/or LAM-resistance excluded
Beckebaum et al, 2018 []14 371/147HBIg+NUC84/6716 (4.3)/0.65%14 (9.5)/1.7%Patients outside the Milan Criteria excluded
Lens et al, 2018 []22 338/113HBIg+NUC72/71.837 (11.0)/1.83%15 (13.3)/2.17%Patients with short- and long-term HBIg treatment
Current study195/83sc HBIg+NUC24/20.57 (3.6)/2.01%4 (4.8)/2.88%High variability regarding time to first sc HBIg treatment after LT – from days to years
AR – annual rate; HBIg – hepatitis B immunoglobulin; HCC – hepatocellular carcinoma; LAM – lamivudine; LT – liver transplantation; N – all study patients (total); n – subgroup of patients with HCC at time of LT; NUC – nucleos(t)ide analog.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358