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20 December 2022: Original Paper

Potential Utility of Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte, and Neutrophil, Lymphocyte, and Platelet Ratios in Differential Diagnosis of Kidney Transplant Acute Rejection: A Retrospective, Propensity Score Matched Analysis

Aureliusz Kolonko 1ABCDEF* , Tomasz Dwulit 1BDE , Michał Skrzypek 2CDE , Andrzej Więcek 1E

DOI: 10.12659/AOT.937239

Ann Transplant 2022; 27:e937239

Table 1 Clinical characteristics of study subgroups with and without early acute rejection episode in the early post-transplant period.

VariableAcute rejection n=71No rejection n=71Statistics
Recipients age [years]51.4 (48.5–54.4)51.7 (49.1–54.3)0.89
Sex [M/F]37/3439/320.74
BMI [kg/m]26.0 (25.0–26.9)25.4 (24.5–26.4)0.43
Dialysis vintage [months]*31 (22–63)29 (20–40)0.27
Diabetes [n (%)]9 (12.7)13 (18.3)0.36
Post-transplant observation time [months]46 (41–51)46 (41–51)0.89
Last PRA >20% [n (%)]6 (8.6)6 (8.6)1.0
Transplant No [1/2/3]53/15/356/14/10.57
Donor age [years]47.6 (44.4–50.8)46.9 (43.9–49.9)0.77
Donor serum creatinine >1.5 mg/dl [n (%)]24 (33.8)21 (29.6)0.59
ECD status [n (%)]22 (31.9)20 (28.2)0.71
CIT [h]18.1 (16.5–19.7)17.6 (15.9–19.3)0.69
HLA class I mismatch2.3 (2.1–2.6)2.1 (1.9–2.3)0.22
HLA class II mismatch0.73 (0.59–0.88)0.63 (0.49–0.77)0.33
Induction therapy (ATG/IL-2RB/none)19/38/1417/39/150.92
Initial graft function (IGF/SGF/DGF)11/33/2715/34/220.57
Initial tacrolimus level [ng/ml]14.1 (12.3–16.0)13.2 (11.7–14.8)0.47
Tacrolimus level at 7–9 POD [ng/ml]7.9 (7.3–8.4)8.4 (7.6–9.1)0.27
Mycophenolate mofetil initial dose [g/day]*1.0 (1.0–1.5)1.0 (1.0–1.5)0.98
Data presented as means with 95% confidence interval or * medians with Q25–Q75 quartile values or frequencies. BMI – body mass index; PRA – panel-reactive antibodies; HLA – human leukocyte antigen; MICA – human major histocompatibility complex class I-related gene A; ECD – extended criteria donor; CIT – cold ischemia time; ATG – antithymocyte globulin; IL-2RB – interleukin-2 receptor blocker; IGF – immediate graft function; SGF – slow graft function; DGF – delayed graft function; POD – post-operative day.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358