30 September 2022: Original Paper
Network Pharmacology-Based Exploration of the Therapeutic Mechanisms of in Renal Ischemia/Reperfusion
Jiajun Dong 1BCEF* , Mingyang Cao 2BCEF* , Hui Yu 3BCEF* , Yang Dong 24AD , Conghui Han 124AG*DOI: 10.12659/AOT.937469
Ann Transplant 2022; 27:e937469
Supplementary Table 1 Information of Cordyceps cicadae and Renal IR-related targets. By combining the related targets of active ingredients of Cordyceps cicadae and the disease related targets, 81 overlapping targets were selected as the key targets in the treatment of renal IRI.
| Ingredient | Gene | Name | Target class |
|---|---|---|---|
| Cordycepin | Neural cell adhesion molecule 1 | – | |
| Proheparin-binding EGF-like growth factor | Complex (toxin/growth factor) | ||
| Collagen alpha-1(XX) chain | Signaling protein | ||
| Fibronectin | – | ||
| Cytochrome P450 2C8 | – | ||
| cAMP-specific 3,5-cyclic phosphodiesterase 4A | Hydrolase | ||
| Complement C3 | – | ||
| Cordycepic acid | C-C motif chemokine 26 | Cytokine | |
| Insulin receptor | Transferase/signaling protein | ||
| Serum albumin | Transport protein | ||
| Vitamin K-dependent protein C | – | ||
| Cyclin-dependent kinase 5 activator 1 | Complex (kinase/activator) | ||
| LXR-alpha | Nuclear receptor | ||
| Sonic hedgehog protein (by homology) | Unclassified protein | ||
| Estrogen receptor alpha | Nuclear receptor | ||
| Caspase-3 | Protease | ||
| Prostanoid EP2 receptor | Family A G protein-coupled receptor | ||
| Neuronal acetylcholine receptor protein alpha-7 subunit | Ligand-gated ion channel | ||
| Angiotensin-converting enzyme | Protease | ||
| Cyclooxygenase-1 | Oxidoreductase | ||
| Maltase-glucoamylase | Hydrolase | ||
| Sucrase-isomaltase | Enzyme | ||
| Solute carrier family 22 member 6 (by homology) | Electrochemical transporter | ||
| Basic fibroblast growth factor | Secreted protein | ||
| Leucine aminopeptidase | Protease | ||
| Glucose-6-phosphate 1-dehydrogenase | Enzyme | ||
| Peroxisome proliferator-activated receptor alpha | Nuclear receptor | ||
| Fatty acid binding protein muscle | Fatty acid binding protein family | ||
| Peroxisome proliferator-activated receptor delta | Nuclear receptor | ||
| Fatty acid binding protein intestinal | Fatty acid binding protein family | ||
| HMG-CoA reductase | Oxidoreductase | ||
| Adenosine | von Willebrand factor | Immune system | |
| Matrix metalloproteinase-9 | Hydrolase | ||
| HLA class I histocompatibility antigen, alpha chain G | Immune system | ||
| Membrane primary amine oxidase | Oxidase | ||
| Adenosine A1 receptor | Family A G protein-coupled receptor | ||
| Adenosine A2a receptor | Family A G protein-coupled receptor | ||
| Adenosine kinase | Enzyme | ||
| Adenosine A3 receptor | Family A G protein-coupled receptor | ||
| Heat shock cognate 71 kDa protein | Other cytosolic protein | ||
| 78 kDa glucose-regulated protein | Unclassified protein | ||
| Adenosine deaminase | Hydrolase | ||
| Glyceraldehyde-3-phosphate dehydrogenase liver | Oxidoreductase | ||
| S-adenosylmethionine decarboxylase 1 | Enzyme | ||
| Tyrosine-protein kinase SRC | Kinase | ||
| Adenosine A2b receptor | Family A G protein-coupled receptor | ||
| MAP kinase ERK2 | Kinase | ||
| Equilibrative nucleoside transporter 1 | Electrochemical transporter | ||
| Purine nucleoside phosphorylase | Enzyme | ||
| Histone-lysine N-methyltransferase SETD2 | Writer | ||
| Purinergic receptor P2Y1 | Family A G protein-coupled receptor | ||
| Purinergic receptor P2Y11 | Family A G protein-coupled receptor | ||
| EZH2/SUZ12/EED/RBBP7/RBBP4 | Writer | ||
| MAP kinase-activated protein kinase 2 | Kinase | ||
| Heat shock 70 kDa protein 1 | Other cytosolic protein | ||
| Serine/threonine-protein kinase PIM1 | Kinase | ||
| Poly(ADP-ribose) glycohydrolase | Enzyme | ||
| Glycogen synthase kinase-3 beta | Kinase | ||
| D-amino-acid oxidase | Enzyme | ||
| Cathepsin L | Protease | ||
| Thrombin | Protease | ||
| Indoleamine 2,3-dioxygenase | Enzyme | ||
| Hexokinase type II | Enzyme | ||
| Rho-associated protein kinase 2 | Kinase | ||
| cAMP-dependent protein kinase alpha-catalytic subunit | Kinase | ||
| Adenylate cyclase type 10 | Enzyme | ||
| Tyrosinase | Oxidoreductase | ||
| Purinergic receptor P2Y12 | Family A G protein-coupled receptor | ||
| Cordycepin & Adenosine | Interleukin-10 | Transferase | |
| Cordycepic acid & Adenosine | Protein-glutamine gamma-glutamyltransferase E | Immune system | |
| Amine oxidase [flavin-containing] A | – | ||
| E3 ubiquitin-protein ligase SMURF2 | – | ||
| Dipeptidyl peptidase IV | Protease | ||
| Carbonic anhydrase II | Lyase | ||
| Carbonic anhydrase I | Lyase | ||
| Carbonic anhydrase IX | Lyase | ||
| Cordycepin & Cordycepic acid & Adenosine | Protein-glutamine gamma-glutamyltransferase 2 | Transferase | |
| Receptor tyrosine-protein kinase erbB-4 | Cell cycle, signaling protein | ||
| Prostacyclin synthase | Isomerase | ||
| Insulin-like growth factor 1 receptor | Hormone receptor | ||
| NAD-dependent deacetylase sirtuin-3, mitochondrial | – |