30 September 2022: Original Paper
Network Pharmacology-Based Exploration of the Therapeutic Mechanisms of in Renal Ischemia/Reperfusion
Jiajun Dong 1BCEF* , Mingyang Cao 2BCEF* , Hui Yu 3BCEF* , Yang Dong 24AD , Conghui Han 124AG*DOI: 10.12659/AOT.937469
Ann Transplant 2022; 27:e937469
Supplementary Table 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of therapeutic target genes and their corresponding counts, P value, and q-value. Through KEGG enrichment of the key targets, the remarkably (P value ≤0.01) enriched pathways were obtained, indicating that numerous targets were involved in the occurrence and development of renal IRI.
| Term | Pathway | Count | p-value | q-value |
|---|---|---|---|---|
| hsa05205 | Proteoglycans in cancer | 14 | 6.27E-09 | 9.24E-07 |
| hsa04611 | Platelet activation | 9 | 2.52E-06 | 0.000185883 |
| hsa05020 | Prion diseases | 5 | 1.86E-05 | 0.000913186 |
| hsa01522 | Endocrine resistance | 7 | 3.93E-05 | 0.001436564 |
| hsa04915 | Estrogen signaling pathway | 8 | 4.87E-05 | 0.001436564 |
| hsa04024 | cAMP signaling pathway | 9 | 0.000208478 | 0.005120512 |
| hsa04213 | Longevity regulating pathway - multiple species | 5 | 0.000302797 | 0.006374676 |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 8 | 0.000387349 | 0.007135378 |
| hsa04010 | MAPK signaling pathway | 10 | 0.000482468 | 0.007751953 |
| hsa00910 | Nitrogen metabolism | 3 | 0.000526025 | 0.007751953 |
| hsa05219 | Bladder cancer | 4 | 0.000608781 | 0.008155917 |
| hsa03320 | PPAR signaling pathway | 5 | 0.000778768 | 0.008556796 |
| hsa04726 | Serotonergic synapse | 6 | 0.000792088 | 0.008556796 |
| hsa04015 | Rap1 signaling pathway | 8 | 0.00086555 | 0.008556796 |
| hsa04612 | Antigen processing and presentation | 5 | 0.000876731 | 0.008556796 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 5 | 0.000929024 | 0.008556796 |
| hsa05135 | Yersinia infection | 6 | 0.00099009 | 0.008582821 |
| hsa04012 | ErbB signaling pathway | 5 | 0.001293045 | 0.009485836 |
| hsa00330 | Arginine and proline metabolism | 4 | 0.001296977 | 0.009485836 |
| hsa04340 | Hedgehog signaling pathway | 4 | 0.001296977 | 0.009485836 |
| hsa05163 | Human cytomegalovirus infection | 8 | 0.001351732 | 0.009485836 |
| hsa04080 | Neuroactive ligand-receptor interaction | 10 | 0.001439263 | 0.009640995 |
| hsa04923 | Regulation of lipolysis in adipocytes | 4 | 0.001852435 | 0.011869146 |
| hsa05134 | Legionellosis | 4 | 0.002114676 | 0.012984852 |
| hsa04510 | Focal adhesion | 7 | 0.002894723 | 0.017063628 |
| hsa05203 | Viral carcinogenesis | 7 | 0.003060907 | 0.017231976 |
| hsa00052 | Galactose metabolism | 3 | 0.003157144 | 0.017231976 |
| hsa04066 | HIF-1 signaling pathway | 5 | 0.003853339 | 0.020280733 |
| hsa04924 | Renin secretion | 4 | 0.004243934 | 0.020402295 |
| hsa05230 | Central carbon metabolism in cancer | 4 | 0.004243934 | 0.020402295 |
| hsa05145 | Toxoplasmosis | 5 | 0.004327464 | 0.020402295 |
| hsa04917 | Prolactin signaling pathway | 4 | 0.004468808 | 0.020402295 |
| hsa04520 | Adherens junction | 4 | 0.004701593 | 0.020402295 |
| hsa00350 | Tyrosine metabolism | 3 | 0.004845545 | 0.020402295 |
| hsa00500 | Starch and sucrose metabolism | 3 | 0.004845545 | 0.020402295 |
| hsa04919 | Thyroid hormone signaling pathway | 5 | 0.005593736 | 0.022898336 |
| hsa05133 | Pertussis | 4 | 0.005988533 | 0.023851911 |
| hsa00260 | Glycine, serine and threonine metabolism | 3 | 0.00652359 | 0.025299241 |
| hsa00230 | Purine metabolism | 5 | 0.008081938 | 0.030539035 |
| hsa05034 | Alcoholism | 6 | 0.008302046 | 0.030586485 |
| hsa04270 | Vascular smooth muscle contraction | 5 | 0.008605365 | 0.030930709 |
| hsa04610 | Complement and coagulation cascades | 4 | 0.008858907 | 0.031083883 |
| hsa05205 | Proteoglycans in cancer | 14 | 6.27E-09 | 9.24E-07 |
| hsa04611 | Platelet activation | 9 | 2.52E-06 | 0.000185883 |
| hsa05020 | Prion diseases | 5 | 1.86E-05 | 0.000913186 |
| hsa01522 | Endocrine resistance | 7 | 3.93E-05 | 0.001436564 |
| hsa04915 | Estrogen signaling pathway | 8 | 4.87E-05 | 0.001436564 |
| hsa04024 | cAMP signaling pathway | 9 | 0.000208478 | 0.005120512 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6 | 6.79E-05 | 0.000132 |
| hsa05133 | Pertussis | 6 | 6.79E-05 | 0.000132 |
| hsa05220 | Chronic myeloid leukemia | 6 | 6.79E-05 | 0.000132 |
| hsa05145 | Toxoplasmosis | 7 | 7.81E-05 | 0.000149 |
| hsa05204 | Chemical carcinogenesis | 6 | 0.000104 | 0.000194 |
| hsa05165 | Human papillomavirus infection | 11 | 0.000207 | 0.000376 |
| hsa04657 | IL-17 signaling pathway | 6 | 0.000209 | 0.000376 |
| hsa05152 | Tuberculosis | 8 | 0.000234 | 0.000408 |
| hsa05146 | Amoebiasis | 6 | 0.000235 | 0.000408 |
| hsa04910 | Insulin signaling pathway | 7 | 0.000261 | 0.000445 |
| hsa04014 | Ras signaling pathway | 9 | 0.000271 | 0.000455 |
| hsa05231 | Choline metabolism in cancer | 6 | 0.000294 | 0.000485 |
| hsa05221 | Acute myeloid leukemia | 5 | 0.000345 | 0.00056 |
| hsa05216 | Thyroid cancer | 4 | 0.000358 | 0.000571 |
| hsa04625 | C-type lectin receptor signaling pathway | 6 | 0.000384 | 0.000603 |
| hsa04928 | Parathyroid hormone synthesis, secretion and action | 6 | 0.000426 | 0.000658 |
| hsa04917 | Prolactin signaling pathway | 5 | 0.000454 | 0.000691 |
| hsa04931 | Insulin resistance | 6 | 0.00047 | 0.000705 |
| hsa04921 | Oxytocin signaling pathway | 7 | 0.000511 | 0.000754 |
| hsa04630 | JAK-STAT signaling pathway | 7 | 0.000719 | 0.001046 |
| hsa04071 | Sphingolipid signaling pathway | 6 | 0.000787 | 0.001129 |
| hsa04152 | AMPK signaling pathway | 6 | 0.000823 | 0.001163 |
| hsa05144 | Malaria | 4 | 0.001055 | 0.00147 |
| hsa04068 | FoxO signaling pathway | 6 | 0.001351 | 0.001857 |
| hsa05202 | Transcriptional misregulation in cancer | 7 | 0.001612 | 0.002185 |
| hsa05142 | Chagas disease (American trypanosomiasis) | 5 | 0.002592 | 0.003466 |
| hsa04620 | Toll-like receptor signaling pathway | 5 | 0.002703 | 0.003567 |
| hsa01523 | Antifolate resistance | 3 | 0.002861 | 0.003724 |
| hsa04920 | Adipocytokine signaling pathway | 4 | 0.003745 | 0.004813 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 4 | 0.003945 | 0.005004 |
| hsa04726 | Serotonergic synapse | 5 | 0.004171 | 0.005224 |
| hsa00982 | Drug metabolism – cytochrome P450 | 4 | 0.004365 | 0.005332 |
| hsa05218 | Melanoma | 4 | 0.004365 | 0.005332 |
| hsa05140 | Leishmaniasis | 4 | 0.004815 | 0.00581 |
| hsa04110 | Cell cycle | 5 | 0.005738 | 0.00684 |
| hsa00983 | Drug metabolism – other enzymes | 4 | 0.006073 | 0.007153 |
| hsa04140 | Autophagy – animal | 5 | 0.006553 | 0.007628 |
| hsa04662 | B cell receptor signaling pathway | 4 | 0.006924 | 0.007966 |
| hsa04930 | Type II diabetes mellitus | 3 | 0.008748 | 0.009893 |
| hsa04020 | Calcium signaling pathway | 6 | 0.008799 | 0.009893 |
| hsa05323 | Rheumatoid arthritis | 4 | 0.009941 | 0.011052 |