27 September 2022 : Original article
Using Postoperative Coagulation Parameters Within 24 h After Liver Transplantation to Predict Incidence of Stage 3 Acute Kidney Injury (AKI)
Chen Chen1BCD, Xiaolan Chen2BC, Xianyuan Zhao1D, Junqi Feng1E, Yuan Gao1E, Yuxiao Deng
1EF, Zhe Li1EF*
DOI: 10.12659/AOT.937535
Ann Transplant 2022; 27:e937535
Table 2 Comparison of liver function and coagulation parameters between the 2 groups within 24 h of LT.
| Groupn | AKI stage 0–2213 | AKI stage 328 | P value |
|---|---|---|---|
| ALT [ (, ), u/l] | 500 (274, 860) | 815 (269, 2085) | <0.001 |
| AST [ (, ), u/l] | 962 (455, 2006) | 2496 (575, 6979) | <0.001 |
| Scr [ (, ), umol/L] | 79 (64, 102) | 205 (177, 269) | <0.001 |
| PLT count [ (, ), ×10/L] | 52.0 (32.0, 85.0) | 30.5 (19.0, 53.5) | 0.003 |
| ADP-induced PLT aggregation [ (, )] | 38.2 (21.2, 59.3) | 11.2 (7.0, 31.5) | <0.001 |
| AA-induced PLT aggregation [ (, )] | 34.4 (13.1, 63.9) | 5.6 (4.5, 40.6) | 0.003 |
| FII [ (, ), %] | 37.1 (28.9, 52.1) | 40.1 (30.3, 52.1) | 0.885 |
| FV [ (, ), %] | 34.7 (22.9, 51.4) | 16.0 (7.0, 30.5) | <0.001 |
| FVII [ (, ), %] | 47.8 (33.5, 63.8) | 35.0 (26.7, 51.5) | 0.065 |
| FVIII [ (, ), %] | 142.7 (102.3, 193.2) | 96.1 (56.6, 170.6) | 0.005 |
| FIX [ (, ), %] | 51.8 (40.4, 71.1) | 43.6 (31.1, 57.2) | 0.022 |
| FX [ (, ), %] | 43.2 (30.9, 57.2) | 40.3 (28.4, 55.6) | 0.512 |
| FXI [ (, ), %] | 33.4 (24.7, 50.2) | 26.3 (17.5, 45.4) | 0.073 |
| FXII [ (, ), %] | 22.9 (18.6, 29.5) | 19.6 (15.5, 29.9) | 0.088 |
| Protein S [ (, ), %] | 31.0 (17.2, 44.1) | 25.00 (13.60, 32.7) | 0.028 |
| Protein C [ (, ), %] | 41.9 (34.2, 59.6) | 41.5 (29.6, 52.4) | 0.410 |
| Antithrombin III [ (, ), %] | 38.8 (29.8, 49.7) | 27.8 (21.9, 43.8) | 0.002 |
| INR [ (, )] | 1.5 (1.3, 1.8) | 1.9 (1.5, 2.5) | <0.001 |
| D-dimer [ (, ), ug/ml] | 2.1 (1.0, 3.6) | 4.9 (2.0, 37.4) | <0.001 |
| FDP [ (, ), ug/ml] | 13.9 (8.3, 23.7) | 24.3 (12.1, 125.6) | <0.001 |
| FIB [ (, ), g/l] | 1.7 (1.2, 2.2) | 0.9 (0.6, 1.5) | <0.001 |
| R-value [ (, ), min] | 6.8 (5.8, 8.2) | 9.0 (7.8, 14.9) | <0.001 |
| K value [ (, ), min] | 4.0 (2.5, 6.5) | 6.7 (4.8, 8.9) | 0.186 |
| α-angle [ (, ), deg] | 60.2 (52.5, 67.4) | 54.0 (46.1, 59.9) | 0.006 |
| MA [ (, ), mm] | 41.4 (34.5, 51.7) | 33.4 (28.5, 38.6) | 0.005 |
| Ly30 [ (, ), %] | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.753 |
| Setting time [ (, ), min] | 28.8 (26.6, 31.3) | 32.5 (28.9, 38.1) | 0.001 |
| Clot strength [ (, ), d/sc] | 3525.4 (2568.2, 5294.3) | 2312.8 (1931.2, 2952.6) | 0.042 |
| AKI – acute kidney injury; ALT – alanine aminotrans; AST – aspartate transaminase; INR – international normalized ratio; FDP – fibrinogen degradation products; FIB – fibrinogen; PLT – platelet; α-angle – rate of clot formation; K value – coagulation value to 20-mm clot; LY 30 – % of clot lysis at 30min; MA – maximum amplitude (maximum strength of clot); R value – reaction value (value to fibrin formation 2mm clot). | |||