25 April 2023: Original Paper
Levels of Procollagen Type I C-Terminal Pro-Peptide and Galectin-3, Arterial Stiffness Measured By Pulse Wave Velocity, and Cardiovascular Morbidity and Mortality in 44 Patients 2 Years After Kidney Transplantation
Madonna Salib 1CDEFG , Nicolas Girerd 1ADE , Arnaud Simon 2BF , Anna Kearney-Schwartz 34ADE , Kévin Duarte 1BCD , Céline Leroy 1B , Patrick Rossignol 1DE , Athanase Benetos 34BE , Luc Frimat 2DE* , Sophie Girerd 12ADE*DOI: 10.12659/AOT.938137
Ann Transplant 2023; 28:e938137
Table 1 Baseline characteristics of patients.
| Total N=44 | |
|---|---|
| Female (%) | 19 (43.2) |
| Age at transplantation (years) | 53 [46–59] |
| Hypercholesterolemia | 21 (47.7) |
| Smoking | 21 (47.7) |
| Diabetes | 6 (13.6) |
| Previous myocardial infarction or angina | 1 (2.3) |
| Previous strokes | 2 (4.5) |
| Diabetes | 2 (4.5) |
| Glomerulopathy | 11 (25.0) |
| Malformation | 8 (18.2) |
| Polycystic kidney disease | 10 (22.7) |
| Vascular | 4 (9.1) |
| Other | 9 (20.5) |
| 34 (77.3) | |
| Hemodialysis (%) | 27 (79.4) |
| Peritoneal dialysis (%) | 7 (20.6) |
| Dialysis duration (years) | 3.1 [2.1–3.8] |
| Calcineurin inhibitors (%) | 43 (97.7) |
| Cyclosporine (%) | 23 (53.5) |
| Tacrolimus (%) | 20 (46.5) |
| Donor type | |
| Living donor (%) | 4 (9.1) |
| Deceased donor (%) | 40 (90.9) |
| Standard criteria donors (SCD) | 26 (65.0) |
| Expanded-criteria donors (ECD) | 14 (35.0) |
| Duration between the last pre-transplantation PWV and the transplantation (months) | 6.4 [2.6–10.4] |
| Pre-transplantation PWV (m/s), n=43 | 8.7±2.5 |
| Pre-transplantation mean arterial blood pressure (mmHg) | 103±14 |
| Duration between transplantation and post-transplantation PWV (months) | 21.6 [12.8–33.7] |
| Post-transplantation PWV (m/s) | 8.6±2.2 |
| Mean blood pressure at post-transplantation PWV (mmHg) | 96±11 |
| eGFR at one year | 48.0 [38.8–55.2] |
| Follow-up time (years) | 10.8 [8.1–11.9] |
| eGFR at the last contact | 48.0 [24.5–57.5] |
| Back to dialysis or preemptive re-transplantation (%) | 5 (11.4) |
| Graft rejection (%) | 17 (38.6) |
| Death (%) | 13 (29.5) |
| CV event post-transplantation (%) | 14 (31.8) |
| Duration between transplantation and biomarkers measurement (months) | 21.6 [12.8–34.0] |
| eGFR at biomarkers measurement (mL/min/1.73 m) | 42.2±14.2 |
| PICP (ng/mL) | 102.0 [68.5–125.1] |
| Gal-3 (ng/mL) | 15.4 [13.1–20.3] |
| ESRD – end stage renal disease; PWV – pulse wave velocity; eGFR – estimated glomerular filtration rate; CV – cardiovascular; PICP – procollagen type I C-terminal propeptide; Gal-3 – galectin-3. | |