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03 January 2023: Original Paper

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and Relapse Settings: A Retrospective Study in China

Jing Liu 1BCDEF* , Haitao Wang 1BCDF* , Xiaohong Li 1B , Yamei Wu 1B , Yuanyuan Ma 1B , Zhenyang Gu 1B , Fei Li 1B , Meng Li 1BD , Jiayuan Guo 2B , Yu Zhao 1B , Quanshun Wang 1B , Jian Bo 1B , Wenrong Huang 1B , Liping Dou 1BD , Yuanbo Liu 3AEF , Daihong Liu 1BD , Xiaoxiong Wu 1ADF* , Chunji Gao 1ADEFG*

DOI: 10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

Table 2 ASCT as consolidation treatment for patients newly diagnosed with PCNSL.

Sex/agePatientECOGConditioning regimenPre-ASCTPost-ASCTTiming of WBRTN/P engraftment time (days)Toxicity
M/4512BEAMCRCRAfter ASCT9/9Haematologic toxicities, gastrointestinal toxicities
M/2822BEAMCRCR11/22Haematologic toxicities, fever
M/6132TBC-likeCRCR9/21Haematologic toxicities, fever, hepatotoxicity, gastrointestinal toxicities, creatinine increased
F/4842TBC-likeCRCR9/15Haematologic toxicities, fever, gastrointestinal toxicities, mucositis
M/5153TBC-likeCRCR8/15Haematologic toxicities, hepatotoxicity, fever
M/3362Modified TBCCRCR10/15Haematologic toxicities, gastrointestinal toxicities, infection, mucositis, rash
F/2170Modified TBCCRCR12/14Haematologic toxicities, gastrointestinal toxicities, infection
M/6281Modified TBCCRCR16/25Haematologic toxicities
F/3292Modified TBCCRCRBefore ASCT15/25Haematologic toxicities, pneumonia
M/26100Modified TBCCRCR11/31Haematologic toxicities, gastrointestinal toxicities
M/28242.442.4A Wo D
M/6136.26.2A Wo D
F/48411.511.5A Wo D
M/51514.314.3A Wo D
M/3363.33.3A Wo D
F/21712.212.2A Wo D
M/62829.029.0A Wo D
F/32927.927.9A Wo D
M/26102.52.5A Wo D
N/P – neutrophil/platelet; TBC – thiotepa + busulfan + cyclophosphamide; BEAM – carmustine + etoposide + cytarabine + melphalan; Modified TBC – TBC + cladribine + etoposide + cytarabine; CR – complete remission; Cru – unconfirmed CR; HDC – high-dose chemotherapy; PFS – progression-free survival; OS – overall survival; A Wo D – alive without disease; DOD – dead of disease. OS1 and PFS1 were measured from the day of transplantation.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358