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03 January 2023: Original Paper

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and Relapse Settings: A Retrospective Study in China

Jing Liu 1BCDEF* , Haitao Wang 1BCDF* , Xiaohong Li 1B , Yamei Wu 1B , Yuanyuan Ma 1B , Zhenyang Gu 1B , Fei Li 1B , Meng Li 1BD , Jiayuan Guo 2B , Yu Zhao 1B , Quanshun Wang 1B , Jian Bo 1B , Wenrong Huang 1B , Liping Dou 1BD , Yuanbo Liu 3AEF , Daihong Liu 1BD , Xiaoxiong Wu 1ADF* , Chunji Gao 1ADEFG*

DOI: 10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

Table 3 ASCT as salvage treatment for relapsed/refractory patients with PCNSL.

Sex/agePatientECOGNumber of recurrences before ASCTConditioning regimenPre-ASCTPost-ASCTTiming of WBRTNeutrophil/platelet engraftment time (days)
M/561221Modified TBCCR2CR13/15
M/501311Modified TBCCR2CRBefore ASCT13/13
M/221401Modified TBCCR2CR31/35
M/441532Modified TBCPRPRBefore ASCT15/28
F/491624Modified TBCPRCRBefore ASCT16/50
M/591733Modified TBCCRu3PD15/−
M/471830Modified TBCPRCRuBefore ASCT13/13
F/531910Modified TBCCRuCRBefore ASCT12/17
M/402021TBC-likeCRCRBefore ASCT19/108
M/6111Haematologic toxicities, fever, hypokalaemia, gastrointestinal toxicities15.015.0A Wo D
M/5612Haematologic toxicities, fever, rashgastrointestinal toxicities, mucositis9.59.5A Wo D
M/5013Haematologic toxicities, fever, gastrointestinal toxicitiesLeukoencephalopathy27.027.0A Wo D
M/2214Haematologic toxicities, haemorrhagic cystitis33.233.2A Wo D
M/4415Haematologic toxicities, gastrointestinal toxicitiesAlalia, Unresponsive4.54.5TRD
F/4916Haematologic toxicities, gastrointestinal toxicities, infection, mucositis12.712.7A Wo D
M/5917Haematologic toxicities, gastrointestinal toxicities, pneumonia, encephalitis0.530.53TRD
M/4718Haematologic toxicities, gastrointestinal toxicities, infection, hepatotoxicityAlalia19.223.9DOD
F/5319Haematologic toxicities, gastrointestinal toxicities, pneumonia1.81.8A Wo D
M/4020Haematologic toxicities, gastrointestinal toxicities, infection, rash, hypokalaemia, mucositis7.77.7A Wo D
TBC – thiotepa + busulfan + cyclophosphamide; Modified TBC – TBC + cladribine + etoposide + cytarabine; CR – complete remission; Cru – unconfirmed CR; HDC – high-dose chemotherapy; PFS – progression-free survival; OS – overall survival; A Wo D – alive without disease; DOD – dead of disease; TRD – treatment-related death. OS1 and PFS1 were measured from the day of transplantation.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358