16 May 2023 : Original article
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections Due to Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae
Piotr Wilkowski1ABCDEF, Ewa Hryniewiecka
1BCDEF, Kornelia Jasińska2BCDEF, Leszek Pączek 1ACDEF, Michał Ciszek 1ABCDEF*
DOI: 10.12659/AOT.939258
Ann Transplant 2023; 28:e939258
Table 2 Demographic, clinical, and microbiological characteristics of the study group.
| Patient No. | Sex/age [years] | Tx type | KP ESBL+ intestinal carriage | Urinary tract abnormality | No. of UTI recurrence before study | Baseline eGFR [ml/min/1.73 m2] | EOT eGFR [ml/min/1.73 m2] | Body weight [kg] |
|---|---|---|---|---|---|---|---|---|
| 1 | M/44 | K | nd | Ureteral stenosis | 3 | 55 | 50 | 95 |
| 2 | M/69 | K | No | No | 1 | 37 | 44 | 63 |
| 3 | M/53 | K | Yes | Urethral stenosis | 3 | 44 | 46 | 90 |
| 4 | M/58 | K | Yes | No | 5 | 23 | 31 | 92 |
| 5 | F/68 | K | Yes | Infected cyst | 3 | 56 | 44 | 53 |
| 6 | M/79 | No | No | Urethral stenosis | 4 | 46 | 40 | 90 |
| 7 | F/73 | K | nd | No | 5 | 20 | 21 | 69 |
| 8 | F/69 | K | Yes | No | 0 | 41 | 40 | 44 |
| 9 | F/63 | L | No | No | 1 | 29 | 27 | 74 |
| Tx – organ transplanted; K – kidney; L – liver; KP ESBL(+) – extended-spectrum beta-lactamase-producing ; UTI – urinary tract infection; eGFR – estimated glomerular filtration rate; nd – no data; EOT – end of treatment. | ||||||||