Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections Due to Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae

16 May 2023 : Original article

Piotr Wilkowski^1ABCDEF, Ewa Hryniewiecka

^1BCDEF, Kornelia Jasińska^2BCDEF, Leszek Pączek

^1ACDEF, Michał Ciszek

^1ABCDEF*

DOI: 10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

Background Material and Methods Results Discussion Conclusions References

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Table 3 Antibiotic susceptibility of K. pneumoniae strains in urine cultures.

Case No	1	2	3	4	5	6	7	8	9
Amikacin	S≤2	S≤2	I=4	S≤2	S≤2	S≤2	S≤2	I=16	I=16
Amoxicillin/Clavulanate	I=8	R=16	R≥32	R≥32	R≥32	R≥32	R≥32	S=8	R≥32
Ampicillin	R≥32	R≥32	R≥32	R≥32	nd	R≥32	R ≥32	R≥32	R≥32
Cefalexin	R≥64	R≥64	R≥64	R≥64	R≥32	R≥64	R≥64	R≥64	R≥64
Cefepime	R=16	R≥32	R≥32	R≥32	R≥16	R≥32	R≥32	R≥32	R≥32
Cefotaxime	R≥64	R≥64	R≥64	R≥64	R≥32	R≥64	R≥64	R≥64	R≥64
Ceftazidime	R≥64	R=32	R≥64	R=32	R=32	R=32	R=32	R≥64	R≥64
Cefuroxime	nd	R≥64	R≥64	R≥64	R≥32	R≥64	R≥64	R≥64	R≥64
Cefuroxime axetil	R≥64	R≥64	R≥64	R≥64	nd	R≥64	R≥64	R≥64	R≥64
Ceftriaxone	nd	R	R	R	nd	R	R	R	R
Ciprofloxacin	R≥4	R=1	R≥4	R≥4	R≥2	R=2	R≥4	R≥4	R≥4
Ertapenem	S≤0,5	S≤0.12	S≤0.12	S≤0.12	S≤0.12	S≤0.12	S≤0.12	S≤0.12	S≤0.12
Gentamicin	R≥16	S≤1	S≤1	S≤1	S≤1	S≤1	S≤1	R≥16	R≥16
Imipenem	S≤0.25	S	S	S	S≤0.25	S	S	S	S
Meropenem	S	S≤0.25	S≤0.25	S≤0.25	S≤0.25	S≤0.25	S≤0.25	S≤0.25	S≤0.25
Norfloxacin	R≥16	R=2	R≥4	R≥16	R≥16	R=4	R≥16	R≥16	R≥16
Piperacillin/Tazobactam	R≥128	I=16	R≥128	R≥32	R=32	I=16	R=32	R≥32	R≥128
Trimethoprim/Sulfamethoxazole	R≥320	R≥320	R≥320	R≥320	R≥16	R≥320	R≥320	R=160	S≤20
S – susceptible; I – intermediate susceptibility; R – resistant; nd – no data.

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