27 June 2023: Original Paper
A 15-Year Retrospective Study of Supportive Extracorporeal Therapies Including Plasma Exchange and Continuous Venovenous Hemodiafiltration of 114 Adults with Acute Liver Failure Awaiting Liver Transplantation
Ilhan Ocak ABCDEFG*DOI: 10.12659/AOT.939745
Ann Transplant 2023; 28:e939745
Table 4 Liver transplantation candidates (underwent liver transplantation after last supportive extracorporeal therapy) and non-liver transplant.
| Initial values* before SET | Last values* after SET | P values | |
|---|---|---|---|
| LT candidates | |||
| AST (IU/L) | 1635 (1108) | 187 (84) | |
| ALT (IU/L) | 1715 (1142) | 199.5 (83.25) | |
| Lactate (mmol/L) | 5.75 (1.15) | 1.7 (0.2) | |
| Ammonia (μmol/L) | 128 (28.5) | 78 (16) | |
| Total bilirubin (mg/dL) | 19.25 (8.18) | 6.1 (3.92) | |
| PT/INR | 3.35 (0.7) | 1.8 (0.1) | |
| pH | 7.3 (0.1) | 7.4 (0.1) | |
| MAP | 55 (6) | 67 (2) | |
| Creatinine | 1.4 (0.3) | 0.55 (0.22) | |
| Heart rate | 120 (22.5) | 93 (8) | |
| PaO/FiO | 285 (36.25) | 305 (18.25) | |
| Platelets | 45 (17.25) | 60 (15) | |
| Bicarbonate | 17.2 (2.43) | 23.1 (1.17) | |
| Non-liver transplant | |||
| AST (IU/L) | 2645 (1817) | 184 (120.5) | |
| ALT (IU/L) | 2755 (1947) | 195 (108.5) | |
| Lactate (mmol/L) | 6 (2.8) | 1.25 (0.65) | |
| Ammonia (μmol/L) | 132 (46.5) | 54 (16) | |
| Total bilirubin (mg/dL) | 8.2 (3.97) | 2.3 (0.8) | |
| PT/INR | 3.4 (0.77) | 1.3 (0.2) | |
| pH | 7.3 (0.1) | 7.4 (0.1) | |
| MAP | 55 (6) | 67 (2) | |
| Creatinine | 1.4 (0.5) | 0.6 (0.2) | |
| Heart rate | 127 (20) | 90 (12) | |
| PaO/FiO | 268 (30.75) | 301 (25) | |
| Platelets | 56 (23.5) | 87 (26) | |
| Bicarbonate | 17.25 (2.58) | 22.9 (1) | |
| * Median (IQR). LT – liver transplantation; SET – supportive extracorporeal eherapy; AST – aspartate transaminase; ALT – alanine tranaminase; PT – prothrombin time; INR – international normalized ratio; MAP – mean arterial pressure. | |||