27 June 2023: Original Paper
A 15-Year Retrospective Study of Supportive Extracorporeal Therapies Including Plasma Exchange and Continuous Venovenous Hemodiafiltration of 114 Adults with Acute Liver Failure Awaiting Liver Transplantation
Ilhan Ocak ABCDEFG*DOI: 10.12659/AOT.939745
Ann Transplant 2023; 28:e939745
Table 5 Initial values of the survivors and ex-patients (deaths).
| * Values of survivors before SET | * Values of ex-patients after SET | P values | |
|---|---|---|---|
| Initial values | |||
| AST (IU/L) | 2465 (1191.25) | 4577.5 (1790) | |
| ALT (IU/L) | 2435 (1180) | 4561.5 (1670) | |
| Lactate (mmol/L) | 5.7 (1.53) | 10.15 (3.03) | |
| Ammonia (μmol/L) | 128 (34.5) | 205 (22.25) | |
| Total bilirubin (mg/dL) | 9.3 (8.48) | 12.6 (8.97) | 0.424 |
| PT/INR | 3.4 (0.5) | 4.35 (0.63) | |
| pH | 7.3 (0.1) | 7.2 (0.02) | |
| MAP | 55 (5) | 50.5 (5.25) | |
| Creatinine | 1.3 (0.42) | 1.7 (0.45) | |
| Heart rate | 126 (18) | 131 (24) | |
| PaO/FiO | 270 (35.5) | 260 (28) | 0.027 |
| Platelets | 57 (23) | 46.5 (28) | 0.331 |
| Bicarbonate | 17.45 (1.93) | 13.25 (3.35) | |
| Last values | |||
| AST (IU/L) | 177.5 (110.75) | 249.5 (203.75) | 0.192 |
| ALT (IU/L) | 189 (86.75) | 240.5 (189.5) | 0.174 |
| Lactate (mmol/L) | 1.2 (0.7) | 1.85 (0.73) | 0.02 |
| Ammonia (μmol/L) | 54.5 (14) | 63 (13.75) | 0.393 |
| Total bilirubin (mg/dL) | 2.2 (1) | 2.5 (1.05) | 0.707 |
| PT/INR | 1.2 (0.3) | 1.3 (0.33) | 0.632 |
| pH | 7.3 (0.1) | 7.4 (0.1) | 0.852 |
| MAP | 66.5 (2.25) | 67 (4.25) | 0.144 |
| Creatinine | 0.5 (0.3) | 0.8 (0.33) | 0.03 |
| Heart rate | 89 (13) | 92 (10) | 0.948 |
| PaO/FiO | 301 (30) | 20.5 (20) | 0.808 |
| Platelets | 86 (27) | 95 (29) | 0.106 |
| Bicarbonate | 22.9 (1) | 22.85 (0.93) | 0.742 |
| Median (IQR). Ex-patient: Death, LT – liver transplantation; SET – supportive extracorporeal therapy; AST – aspartate transaminase; ALT – alanine tranaminase; PT – prothrombin time; INR – international normalized ratio; MAP – mean arterial pressure. | |||