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15 August 2023 : Review article  

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

Joanna Raszeja-Wyszomirska ORCID logo1ADEF, Michał Macech ORCID logo2EF, Monika Kolanowska ORCID logo3D, Marek Krawczyk ORCID logo4AD, Sławomir Nazarewski ORCID logo2ADEF, Anna Wójcicka3D, Jolanta Małyszko ORCID logo5ADEFG*

DOI: 10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

Authors information Article notes Copyright and License information

Table 1 Summary of the studies on cfDNA in regard to type of organ, source (plasma/urine or both) and technology platform used.

Author, year of publicationGraftNo. of recipientsSampleTechnology platform (target)
Lui [], 200359 Heart, kidney, liver31PlasmaQuantitative PCR (SRY genes)
Gadi [], 200629 Pancreas – kidney42PlasmaQuantitative PCR (HLA specific genes)
Snyder [], 20119 Heart44PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
Macher [], 201460 Liver10PlasmaDroplet digital PCR (SRY genes)
De Vlaminck [], 201438 Heart65PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
De Vlaminck [], 201561 Lung51PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
Schutz [], 201714 Liver107PlasmaDroplet digital PCR (single-nucleotide polymorphisms)
Bloom [], 201762 Kidney102PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Ragalie [], 201863 Heart88PlasmaQuantitative PCR (single-nucleotide polymorphisms)
Whitlam [], 201964 Kidney55PlasmaDroplet digital PCR (single-nucleotide polymorphisms)
Oellerich [], 201917 Kidney189PlasmaDroplet digital PCR (single-nucleotide polymorphisms)
Huang [], 201965 Kidney63PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Khush [], 201966 Heart740PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
North [], 202067 Heart76PlasmaQuantitative PCR (single-nucleotide polymorphisms)
Dauber [], 202068 Kidney29PlasmaQuantitative PCR (Insertion and deletion mutations)
Gielis [], 202069 Kidney107PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
Zhang [], 202070 Kidney37PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
Pulliyanda [], 202071 Kidney67PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Sayah [], 202072 Lung69PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Richmond [], 202030 heart174PlasmaOne-genome genotyping
Agbor-Enoh [], 202145 heart171PlasmaTwo-genome genotyping
Zhou [], 202173 Kidney120UrineNext-generation sequencing (single-nucleotide polymorphisms)
Khush []202174 lung38PlasmaTargeted SNPs
Jang [], 202175 lung148PlasmaTwo-genome genotyping
Obrisca [], 202250 Kidney171PlasmaLuminex and CareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Kueng [], 202276 Kidney, Liver121Plasma, urineDroplet digital PCR (SRY gene, HLA specific genes)
Chen [], 202277 Kidney113Plasma, urineNext-generation sequencing (single-nucleotide polymorphisms)
Levitsky [], 202222 Liver219PlasmaNext-generation sequencing (single-nucleotide polymorphisms)
Bu [], 202242 Kidney1092PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Halloran [], 202249 Kidney289PlasmaProspera – Next-generation sequencing (single-nucleotide polymorphisms)
Sedej [], 202253 Kidney40UrineFluorometry and digital droplet PCR
Amadio [], 202234 Heart90PlasmaCareDx – Next-generation sequencing (single-nucleotide polymorphisms)
Rodgers [], 202335 heart112PlasmaStandard SNPAlloSure; CareDx; Brisbane, California, expanded SNP Prospera™; Natera; Austin, Texas and gene expression profiling (GEP) AlloMap® AlloMap®; CareDx; Brisbane, California
Henricksen [], 202336 Heart159Plasmadd-cfDNA (AlloSure, CareDx, Brisbane, CA) and gene expression profiling (GEP) AlloMap, CareDx, Brisbane, CA
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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358