20 June 2023: Original Paper
Survival Analysis of Transplant-Associated Thrombotic Microangiopathy Under Different Diagnostic Criteria and Efficacy of Plasma Exchange
Yifan Xu 12ABCDEF , Yan Wei 12BF , Lijun Wang 2BC , Ning Lu 2BD , Yongli Wu 2BD , Liping Dou 2AF , Daihong Liu 2AF , Meng Li 2ADEF* , Chunji Gao 2ADEFG*DOI: 10.12659/AOT.939890
Ann Transplant 2023; 28:e939890
Table 2 Univariate analysis of the efficacy of PE for TA-TMA.
| Variable | Response to PE | P value | |
|---|---|---|---|
| NR (n=12) | CR/PR (n=9) | ||
| 139.5 (41–591) | 67.0 (22–179) | ||
| ABO compatibility | 8 (66.7%) | 7 (77.8%) | 0.659 |
| HLA matched | 4 (33.3%) | 2 (22.2%) | 0.659 |
| Sex matched | 8 (66.7%) | 6 (66.7%) | >0.99 |
| III–IV aGVHD prior to TA-TMA, n (%) | 8 (66.7%) | 3 (33.3%) | 0.198 |
| EBV/CMV infections preceding TA-TMA, n (%) | 10 (83.3%) | 7 (77.8%) | >0.99 |
| Elevated total bilirubin | 8 (66.7%) | 1 (11.1%) | |
| GI bleeding | 9 (75.0%) | 6 (66.7%) | >0.99 |
| Proteinuria | 6 (50.0%) | 7 (77.8%) | |
| Hypoproteinemia | 10 (83.3%) | 6 (66.7%) | 0.611 |
| Hypertension | 4 (33.3%) | 4 (44.4%) | |
| Renal or neurological dysfunction | 8 (66.7%) | 1 (11.1%) | |
| Bacterial infection | 12 (100.0%) | 8 (88.9%) | 0.429 |
| Hb (g/L), mean | 59.5±9.2 | 76.2±12.3 | |
| PLT (×10/L), median | 11.5 (3–32) | 35 (7–165) | 0.577 |
| LDH (U/L), median | 536.8 (196.6–1790.4) | 314.9 (244.9–665.0) | 0.286 |
| Schistocytes (%), median | 1.5 (0.0–4.0) | 1.5 (0.0–2.6) | 0.583 |
| TBIL (μmol/L), median | 40.4 (4.7–329.0) | 9.6 (4.7–34.7) | |
| Initial volume of PE (L), median | 2.0 (1.2–4.0) | 2.4 (1.9–3.5) | 0.924 |
| Cumulative volume of PE (L), median | 9.0 (1.7–25.2) | 15.3 (6.2–51.2) | 0.127 |
| Number of PE sessions, median | 3.5 (1–11) | 6 (2–25) | 0.054 |
| Data are presented as the mean±SD, median (range, minimum-maximum), or n (%). Significant P values are in bold type. HLA – human leukocyte antigen; TBI – total body irradiation; aGVHD – acute graft-versus-host disease; CMV – cytomegalovirus; EBV – Epstein-Barr virus; LDH – lactate dehydrogenase; TBIL – total bilirubin; PE – plasma exchange; GI – gastrointestinal; Hb – hemoglobin; PLT – platelet. | |||