28 November 2023 : Original article
Toll-Like Receptor 3 mRNA Expression of Peripheral Blood Mononuclear Cells Identifies Kidney Recipients with Potential for Improved Graft Performance
Sławomir C. Zmonarski
1ACDE*, Mirosław Banasik 1D, Marcelina Żabińska 1AB, Tomasz Gołębiowski 1BD, Joanna M. Zmonarska 2BF, Magdalena Krajewska 1FG
DOI: 10.12659/AOT.941266
Ann Transplant 2023; 28:e941266
Table 1 Study population.
| Population | No | |
|---|---|---|
| Control | 46 | |
| All patients | 133 | |
| Female patients | 51 | |
| History of DGF (Yes) | 39 | |
| Historical transplant biopsy | 43 | |
| Baseline: tacrolimus (Yes) | 82 | |
| Baseline: cyclosporin A (Yes) | 51 | |
| Baseline: eGFR class 4+5 | 20 | |
| Baseline: eGFR class 3b | 41 | |
| Baseline: eGFR class 3a | 43 | |
| Baseline: eGFR class 2+1 | 29 | |
| UCF (patients) | 48 | |
| FCF (patients) | 73 | |
| Donors: KT age (y) | 44.91 | 13.42 |
| Recipients: KT age (y) | 48.41 | 11.72 |
| Follow-up time (m) | 21.3 | 16.9 |
| Recipient baseline age (y) | 50.9 | 12.45 |
| Time from KT to biopsy (m) | 3.1 | 0.7–9.26 |
| Time from KT to baseline (m) | 11.4 | 3.8–42.8 |
| Baseline eGFR (ml/min) | 48 | 37–59.5 |
| ΔΔCt – the measure of the expression of Toll-like receptors (see “Method”); DGF – delayed graft function; eGFR – estimated glomerular filtration rate; FCF – favorable course of follow-up; KT – kidney transplantation surgery; m – months; No – number of participants. Q25–Q95 – margins of lower and upper quartiles; SD – standard deviation; UCF – unfavorable course of follow-up; y – years. | ||