28 November 2023: Original Paper
Toll-Like Receptor 3 mRNA Expression of Peripheral Blood Mononuclear Cells Identifies Kidney Recipients with Potential for Improved Graft Performance
Sławomir C. Zmonarski 1ACDE* , Mirosław Banasik 1D , Marcelina Żabińska 1AB , Tomasz Gołębiowski 1BD , Joanna M. Zmonarska 2BF , Magdalena Krajewska 1FGDOI: 10.12659/AOT.941266
Ann Transplant 2023; 28:e941266
Table 3 Regression analysis of baseline data.
| Depend. var. | Predictor | Level of effect | β | p= | R2 | F (df;df) | p= |
|---|---|---|---|---|---|---|---|
| All patients | |||||||
| Baseline eGFR | Uric acid (mg/dL) | −0.4 | 0.003 | ||||
| BANFF “t” | −0.3 | 0.024 | |||||
| TLR3-mRNA: Low or High | High | 0.3 | 0.032 | ||||
| Tac. or CsA | Tac. | 0.29 | 0.038 | 0.446 | 6.64 (4: 33) | ||
| HSD: TLR3-mRNA: Low vs High p=0.049 | |||||||
| HSD: Tac. or CsA p=0.186 | |||||||
| TLR3-mRNA expr. | DGF (days) | −0.25 | 0.007 | 0.067 | 7.6 (1: 52) | 0.007 | |
| TLR3-mRNA expr. | Baseline eGFR ml/min | 0–30 | −0.3 | 0.014 | |||
| 31–45 | 0.22 | 0.042 | |||||
| 46–60 | 0.06 | 0.53 | 0.054 | 2.6 (3: 131) | 0.06 | ||
| TLR3-mRNA expr. | BANFF “g” | Abnormal | −0.09 | 0.069 | 0.082 | 3.48 (1: 39) | 0.069 |
| TLR3-mRNA expr. | BANFF “v” | Abnormal | −0.08 | 0.093 | 0.071 | 2.96 (1: 39) | 0.093 |
| Graft recipients with TLR3-mRNA below median | |||||||
| TLR3-mRNA expr. | BANFF “t” | Abnormal | −0.6 | 0.002 | 0.397 | 12.52 (1: 19) | 0.002 |
| TLR3-mRNA expr. | BANFF “v” | Abnormal | −0.49 | 0.015 | 0.271 | 7.07 (1: 19) | 0.015 |
| Graft recipients treated with tacrolimus | |||||||
| TLR3 expr. | M-predn. cum. iv dose (mg) | −0.25 | 0.024 | 0.255 | 5.27 (1: 76) | 0.024 | |
| Banff – Banff conference for allograft pathology classification; CsA – cyclosporin A; Depend. var. – dependent variable; DGF – delayed graft function; eGFR – estimated glomerular filtration rate (ml/min); expr. – expression; HSD – Tukey’s honestly significant difference; M-predn. cum. iv dose (mg) – cumulative dose of intravenous methylprednisolone; SE – standard error; Tac. – tacrolimus; TLR3-mRNA – expression of messenger RNA of Toll-like receptor 3 (Low – mRNA expression below the median for the general cohort of patients; High – mRNA expression over the median for the general cohort of patients). | |||||||