28 November 2023: Original Paper
Toll-Like Receptor 3 mRNA Expression of Peripheral Blood Mononuclear Cells Identifies Kidney Recipients with Potential for Improved Graft Performance
Sławomir C. Zmonarski 1ACDE* , Mirosław Banasik 1D , Marcelina Żabińska 1AB , Tomasz Gołębiowski 1BD , Joanna M. Zmonarska 2BF , Magdalena Krajewska 1FGDOI: 10.12659/AOT.941266
Ann Transplant 2023; 28:e941266
Table 4 Follow-up, regression analysis of UCF and FCF groups.
| Depend. var. | Predictor | Level of Effect | β | p= | R2 | F (df;df) | p= |
|---|---|---|---|---|---|---|---|
| All patients | |||||||
| F-up eGFR | Baseline TLR3-mRNA: Low or High | High | 0.189 | 0.029 | 0.035 | 4.9 (1: 133) | 0.029 |
| Favorable course of follow-up (FCF) | |||||||
| TLR3-mRNA expr. | Donor age (y) | −0.36 | 0.003 | 0.132 | 9.76 (1: 64) | 0.003 | |
| TLR3-mRNA expr. | Tacrolimus (mg/kg) | −0.29 | 0.037 | 0.085 | 4.57 (1: 49) | 0.037 | |
| TLR3-mRNA expr. | BMI (Low, Norm, Obese) | Obese | 0.45 | 0.074 | |||
| Low | −0.55 | 0.001 | 0.136 | 5.74 (1: 73) | 0.004 | ||
| F-up eGFR | TLR3-mRNA expression (ΔΔCt) | 0.21 | 0.063 | 0.208 | 3.56 (1: 79) | 0.063 | |
| Unfavorable course of follow-up (UCF) | |||||||
| TLR3-mRNA expr. | DGF (days) | −0.34 | 0.032 | 0.119 | 4.97 (1: 37) | 0.032 | |
| TLR3-mRNA expr. | Tacrolimus conc. (ng/l) | 0.44 | 0.013 | 0.201 | 7.04 (1: 28) | 0.013 | |
| TLR3-mRNA expr. | BMI (Low, Norm, Obese) | Norm | 0.34 | 0.023 | |||
| Obese | −0.53 | 0.72 | 0.114 | 2.77 (2: 43) | 0.074 | ||
| BMI – body mass index; conc. – concentration; ΔΔCt – measure and method of expression of Toll-like receptors; Depend. var. – dependent variable; eGFR – estimated glomerular filtration rate (ml/min); F-up – follow-up; Tac. – tacrolimus; TLR3-mRNA – baseline expression of mRNA of Toll-like receptor 3 (Low – below median, High – over median). | |||||||