05 December 2023>: Database Analysis
Survival Outcomes After Double-Lung Transplantation for Refractory Lung-Limited Cancers and Incidence of Post-Transplant Lung Cancer
Jeeyeon Lee 12ABCDEF , Maria Jose Aguilera Chuchuca 1CDF , Jisang Yu 1BC , Liam Il-Young Chung 1AEF , Ankit Bharat 1ABCDEFG* , Young Kwang Chae 1A*DOI: 10.12659/AOT.941301
Ann Transplant 2023; 28:e941301
Table 1 Cancer-related factors in patients who received double-lung transplantation (DLT) for lung cancer from case series, Organ Procurement Transplantation Network (OPTN) registry.
Variables | Case series (n=20) | OPTN data (n=15) | ||||||
---|---|---|---|---|---|---|---|---|
p-value | p-value | |||||||
n (%) | Recurrence | Death | Cancer-specific death | n (%) | Recurrence | Death | Cancer-specific death | |
Age at transplantation | ||||||||
≤50 | 13 (65.0) | 0.129 | 0.698 | 0.203 | 6 (40.0) | 0.091 | 0.111 | 0.062 |
>50 | 7 (35.0) | 9 (60.0) | ||||||
Gender | ||||||||
Male | 9 (45.0) | 0.312 | 0.958 | 0.505 | 9 (60.0) | 0.821 | 0.242 | 0.650 |
Female | 11 (55.0) | 6 (40.0) | ||||||
Smoking history* | ||||||||
Non-smoker | 8 (40.0) | 0.063 | 0.122 | 0.063 | 9 (60.0) | 0.471 | 0.660 | 0.351 |
Smoker | 3 (15.0) | 6 (40.0) | ||||||
Unknown | 9 (45.0) | 0 (0.0) | ||||||
Histology of tumor | ||||||||
Bronchioloavleolar carcinoma | 18 (90.0) | 0.524 | 0.292 | 0.808 | 15 (100.0) | – | – | – |
Others | 2 (10.0) | 0 (0.0) | ||||||
Type of DLT* | ||||||||
Sequential | 15 (75.0) | 0.755 | 0.796 | 0.401 | 0 (0.0) | – | – | – |
Non-sequential (En-bloc) | 3 (10.0) | 0 (0.0) | ||||||
Unknown | 2 (10.0) | 15 (100.0) | ||||||
Use of cardiopulmonary bypass* | ||||||||
No | 4 (20.0) | 0.016 | 0.868 | 0.640 | 15 (100.0) | – | – | – |
Yes | 14 (70.0) | 0 (0.0) | ||||||
Unknown | 2 (10.0) | 0 (0.0) | ||||||
* The analysis was conducted only with available data (excluded unknown category). |