12 September 2023 : Original article
Living Donor Liver Transplantation in Patients with Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibodies Using Preoperative Desensitization Therapy According to Intensity of Donor-Specific Antibodies: A Single-Center Study
Kohei Ogawa
1ABCDEF*, Kei Tamura 1AB, Katsunori Sakamoto 1C, Naotake Funamizu 1B, Masahiko Honjo 1B, Mikiya Shine1B, Yusuke Nishi1B, Tomoyuki Nagaoka 1B, Chihiro Ito1B, Miku Iwata1B, Mio Uraoka1B, Yasutsugu Takada 1AD
DOI: 10.12659/AOT.941346
Ann Transplant 2023; 28:e941346
Table 3 Clinical features and outcomes of cross-reactive epitope group antibody (CREG)-alone-positive liver transplant recipients.
| Case | Primary disease | Sex | Age (y) | Donor | Blood type combination | Lymphocyte cross-match | Maximum MFI of CREG class I | Maximum MFI of CREG class II |
|---|---|---|---|---|---|---|---|---|
| 10 | PBC | F | 61 | Daughter | Identical | T cell: positiveB cell: positive | B45: 7279 | – |
| 11 | Wilson disease | M | 37 | Brother | Identical | T cell: negativeB cell: positive | B76: 3551 | – |
| 12 | BA | F | 24 | Father | Identical | T cell: negativeB cell: negative | A1: 10527 | |
| 13 | LC (HBV) | M | 50 | Son | Identical | T cell: negativeB cell: negative | – | DR9: 2884 |
| 14 | LC (NASH) | M | 70 | Wife | Identical | T cell: negativeB cell: negative | A34: 1329 | – |
| 15 | LC (HCV) | F | 61 | Sister | Identical | T cell: negativeB cell: negative | – | DR4: 1147 |
| 16 | AIH | F | 48 | Brother | Identical | T cell: negativeB cell: negative | DR4: 1046 | |
| 10 | MMF | Yes | None | CMV | Alive (2247) | |||
| 11 | MMF | No | None | Bacteremia, CMV | Alive (2114) | |||
| 12 | None | No | TCMR | None | Alive (1106) | |||
| 13 | None | No | None | None | Alive (1071) | |||
| 14 | None | No | TCMR | None | Alive (1540) | |||
| 15 | None | No | TCMR | CMV | Alive (1148) | |||
| 16 | None | No | None | Bacteremia, CMV | Alive (952) | |||
| MFI – mean fluorescence intensity; CREG – cross-reactive epitope group; IVIG – intravenous immune globulin; PBC – primary biliary cholangitis; MMF – mycophenolate mofetil; CMV – cytomegalovirus infection; BA – biliary atresia; TCMR – T-cell mediated rejection; LC – liver cirrhosis; HBV – hepatitis B virus; NASH – non-alcoholic steatohepatitis; HCV – hepatitis C virus; AIH – auto-immune hepatitis. | ||||||||