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26 March 2024: Database Analysis

Outcomes of Renal Transplantation in ANCA-Associated Vasculitis: A Systematic Review and Meta-Analysis

Xiaoqin Long 1AB , Xiaobing Yang 1ABF , Shudong Yao 2ABCD , Jia Wu 2ABCDE*

DOI: 10.12659/AOT.943433

Ann Transplant 2024; 29:e943433

Authors information Article notes Copyright and License information

Table 1 Characteristics of included studies.

First AuthorYearStudy periodStudy designStudy settingStudy locationInclusion criteria
Silva et al []13 20232011–2020Retrospective cohortSingle-centrePortugalAAV with ESKD as her CHCC
Kauffmann et al []14 20212008–2021Retrospective cohortPopulation-databaseFranceRenal failure due to GPA or MPA on dialysis
Rathmann et al []15 20211997–2017Retrospective cohortPopulation-databaseSwedenHistology, ANCA or surrogate markers positive
Kuhnel et al []16 20211990–2018Retrospective cohortPopulation-databaseAustralia & New ZealandPrimary Kidney Disease with ANCA associated Vasculitis
Hasegawa et al []17 20212005–2016Retrospective cohortMulti-centreJapanANCA positive, signs of renal involvement
Miyabe et al []18 20192000–2016Retrospective cohortSingle-centreJapanAAV
Wang et al []19 20192005–2015Retrospective cohortSingle-centreChinaAAV as per CHCC
Park et al []20 20182000–2017Retrospective cohortSingle-centreKoreaAAV as per CHCC
Buttigieg et al []21 20171987–2013Retrospective cohortSingle-centreScotlandANCA positive, signs of renal invlvement
Hasegawa et al []22 20151991–2012Retrospective cohortSingle-centreJapanAAV as per EMAA MPO-ANCA only
Weiner et al []23 20151997–2009Retrospective cohortMulti-centreSweden, UK and Czech Republic≥75y, MPA or GPA as per EMAA
Chen et al []24 20141997–2011Retrospective cohortSingle-centreChinaAAV as per CHCC1 and ACR1, HD/PD >3mo
Merino et al []25 20101989–2008Retrospective cohortMulti-centreSpainPauci-immune GN GPA, EGPA, Anti-GBM
Borao-Cengotita-Bengoa et al []26 20101990–2006Retrospective cohortSingle-centreSpainAAV as per CHCC and ACR (for GPA only)
Lionaki et al []27 20091986–2017Inception cohortMulti-centreUSANCA +ve and ESRD; compared with ANCA +ve and preserved renal function
Weidanz et al []28 20071971–2004Retrospective cohortSingle-centreUKAAV as per CHCC and ACR, Dialysis > 4 weeks
Weidner et al []29 2004NRRetrospective cohortSingle-centreGermanyAAV as per CHCC with biopsy
Booth et al []30 20031995–2000Retrospective cohortMulti-centreUKAAV as per CHCC with renal involvement
Haubitz et al []31 19981976–1993Retrospective cohortSingle-centreGermanyGPA as per CHCC and ACR, undergoing chronic dialysis
Allen et al []32 19981974–1997Retrospective cohortSingle-centreUKAAV as per CHCC who developed ESRD
Schleiffer et al []33 19981984–1993Retrospective cohortSingle-centreGermanyAAV as per CHCC and ACR
Garrett et al []34 19921987–1988Retrospective cohortSingle-centreUKANCA +ve with clinical or histology suggestive of vasculitis
Coward et al []35 1986NRRetrospective cohortSingle-centreUKRenal biopsy of GPA or PAN
Silva et al []13 NR272.2 (0.8)39 (16)NRSurvival
Kauffmann et al []14 Patients not paired with national health data2293.2 (2.3)66 (13)142 GPA, 87 MPASurvival, relapse, infection
Rathmann et al []15 NR325 (51)2.2NRNRInfection
Kuhnel et al []16 Uncertain or unreported cause of kidney failure254NR56 (5)NRSurvival, infection
Hasegawa et al []17 AVR, AS at onset of AAV97 (39)9.2 (5.8)65 (11)2 GPA, 37 MPASurvival
Miyabe et al []18 IHD < 6 months115 (4.1)58 (!5)1 GPA, 10 MPASurvival, relapse
Wang et al []19 Renal Recovery201.9 (2)52 (14)6 GPA, 14 MPASurvival
Park et al []20 NR144 (4)NR37 (16)1 GPA, 3 MPASurvival
Buttigieg et al []21 NR24545 (13)17 GPA, 7 MPASurvival
Hasegawa et al []22 −894.5 (4.3)68 (11)1 GPA, 88 MPASurvival, relapse, infection
Weiner et al []23 EGPA, PAN, Anti-GBM, secondary vasculitis151 (37)1.4***NRNRSurvival
Chen et al []24 Secondary vasculitis, Anti-GBM49NR58 (12)5 GPA, 38 MPA, 6 RLVSurvival
Merino et al []25 GPA, EGPA, Anti-GBM−196.1 (5.8)66 (12)19 MPA or RLVSurvival, relapse
Borao-Cengotita-Bengoa et al []26 Inconclusive or missing biopsy31 (14)8.5 (7.1)52 (20)3 GPA, 11 MPASurvival, relapse
Lionaki et al []27 Patients censored at transplantation452 (93)2 (1.5)56 (22)14 GPA, 48 MPA, 1 EGPA, 49 RLVSurvival, relapse, infection
Weidanz et al []28 Recovered renal function, Anti-GBM, IgAV−462.6 (2.1)58 (17)21 GPA, 24 MPA, 1 EGPASurvival, relapse, infection
Weidner et al []29 No renal involvement80 (18)5.9 (3.4)NR12 GPA, 6 MPASurvival
Booth et al []30 NR246 (68)3.6***NRNRSurvival
Haubitz et al []31 Patients censored at transplantation−353.4 (2.5)45 (18)35 GPASurvival, relapse
Allen et al []32 Recovered renal function, Death within 2 mo of dialysis onset−595.2 (3.3)52 (13–77)**23 GPA, 23 MPA, 3 EGPASurvival, relapse
Schleiffer et al []33 NR23 (9)2.9 (2.8)56 (15)5 GPA, 4 MPASurvival
Garrett et al []34 NR30 (5)1.2***NRNRSurvival, infection
Coward et al []35 SLE, HSP36 (9)*5.0 (3.6)42 (10)6 GPA, 3 MPASurvival
AAV – ANCA associated vasculitis; ANCA – anti-neutrophil cytoplasmic antibody; GPA – granulomatosis with polyangiitis; MPA – microscopic polyangiitis; EGPA – eosinophilic granulomatosis with polyangiitis; ESKD – end stage kidney disease; GBM – glomerular basement membrane; CHCC – Chapel hill consensus conference; ACR – albumin to Creatinine ratio; PAN – Polyarteritis nodosa; SLE – systemic lupus erythromatosis; HSP – Henoch-Schonlein purpura.
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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358