Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Jason Guo; Jorge A. Sanchez-Vivaldi; Madhukar S. Patel; Benjamin K. Wang; Andrew D. Shubin; Yash Kadakia; Jigesh A. Shah; Malcolm MacConmara; Steven Hanish; Parsia A. Vagefi; Christine S. Hwang

doi:10.12659/AOT.944245

06 August 2024 : Original article

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Jason Guo

^1ABCDEF, Jorge A. Sanchez-Vivaldi^23ABCDEF, Madhukar S. Patel^23ADE, Benjamin K. Wang^1ABC, Andrew D. Shubin^23ABCD, Yash Kadakia^1E, Jigesh A. Shah^23E, Malcolm MacConmara

^234DEF, Steven Hanish^23E, Parsia A. Vagefi^23E, Christine S. Hwang^23ACDEF*

DOI: 10.12659/AOT.944245

Ann Transplant 2024; 29:e944245

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Table 1 Graft characteristics of biopsied normal and abnormal liver allografts, as well as demographic and clinical characteristics of the corresponding deceased donors.

	Biopsied normal liver (N=114)	Abnormal liver (N=99)	p-value*

Split liver graft^**	26 (23%)	20 (20%)	0.6
Macrosteatosis (%)^***	0.0 (0.0, 1.8)	5.0 (0.0, 10.0)	<0.001
Cold ischemia time (h)^***	6.0 (5.0, 7.4)	6.5 (5.2, 8.0)	0.2
Distance from procurement center (mi)^***	276.5 (136.0, 463.8)	269.0 (85.5, 451.0)	0.7

Donor age (y)^***	14.5 (2.3, 25.0)	22.0 (7.5, 36.0)	0.002
Donor gender^**			0.5
Male	61 (54%)	48 (49%)
Female	53 (46%)	51 (51%)
Donor ethnicity^**			0.3
White	67 (58%)	56 (57%)
Black	27 (24%)	17 (17%)
Hispanic	19 (17%)	23 (23%)
Other/unknown	1 (1%)	3 (3%)
Donor BMI (kg/m)^***	21.3 (17.6, 23.9)	22.6 (18.7, 25.6)	0.12
Donor AST^***	60.0 (30.0, 104.8)	50.0 (29.0, 145.0)	0.9
Donor ALT^***	48.5 (25.3, 90.0)	57.0 (24.5, 94.0)	0.8
Donor total bilirubin^***	0.6 (0.3, 1.1)	0.7 (0.5, 1.3)	0.2
Heavy alcohol use (2+ drinks/day)^**	6 (5.3%)	7 (7.1%)	0.13
Smoking history^**	5 (4.4%)	9 (9.1%)	0.2
Drug use history^**	28 (25%)	31 (31%)	0.3
Diabetes^**	2 (1.8%)	4 (4.0%)	0.4
Hypertension^**	8 (7.0%)	12 (12%)	0.2
Hepatitis C Ab^**	1 (0.9%)	0 (0.0%)	>0.9
Hepatitis B core Ab^**	0 (0.0%)	1 (1.0%)	0.5
Cancer^**	0 (0.0%)	1 (1.0%)	0.5
Infection^**	90 (79%)	81 (82%)	0.6
DCD donor^**	0 (0.0%)	0 (0.0%)	na
Donor cause of death^**			0.1
Anoxia	59 (53%)	54 (57%)
CVA	8 (7%)	14 (15%)
Other	44 (40%)	27 (28%)
Donor risk index^***	2.0 (1.6, 2.4)	1.8 (1.5, 2.2)	0.1
^* Wilcoxon rank sum test; Pearson’s Chi-squared test; Fisher’s exact test; ^ n (%); ^* median (IQR).

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Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

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