06 August 2024 : Original article
Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?
Jason Guo
1ABCDEF, Jorge A. Sanchez-Vivaldi23ABCDEF, Madhukar S. Patel23ADE, Benjamin K. Wang1ABC, Andrew D. Shubin23ABCD, Yash Kadakia1E, Jigesh A. Shah23E, Malcolm MacConmara 234DEF, Steven Hanish23E, Parsia A. Vagefi23E, Christine S. Hwang23ACDEF*
DOI: 10.12659/AOT.944245
Ann Transplant 2024; 29:e944245
Table 2 Clinical and demographic characteristics of recipients of biopsied normal and abnormal livers.
| Recipient characteristics | Biopsied normal liver (N=114) | Abnormal liver (N=99) | p-value* |
|---|---|---|---|
| Recipient age (y)*** | 3.5 (1.0, 10.0) | 7.0 (1.0, 14.0) | 0.059 |
| Recipient gender** | >0.9 | ||
| Male | 53 (46%) | 46 (46%) | |
| Female | 61 (54%) | 53 (54%) | |
| Recipient ethnicity** | >0.9 | ||
| White | 55 (48%) | 49 (50%) | |
| Black | 20 (17%) | 19 (19%) | |
| Hispanic | 27 (24%) | 23 (23%) | |
| Other/unknown | 12 (11%) | 8 (8%) | |
| PELD at transplant*** | 13 (0, 21) | 17 (8, 30.5) | 0.011 |
| Recipient BMI (kg/m)*** | 17.5 (16.0, 20.8) | 18.2 (16.0, 20.9) | 0.9 |
| Time on waitlist (d)*** | 53 (11, 116) | 39 (6, 96) | 0.12 |
| Prior liver transplant** | 5 (4.4%) | 10 (10%) | 0.10 |
| Cause of liver disease** | |||
| Acute hepatic necrosis | 9 (7.9%) | 15 (15%) | |
| Biliary atresia/hypoplasia | 36 (32%) | 30 (30%) | |
| Cirrhosis | 8 (7.0%) | 13 (13%) | |
| Congenital hepatic fibrosis | 1 (0.9%) | 1 (1.0%) | |
| Cystic fibrosis | 2 (1.8%) | 2 (2.0%) | |
| Familial cholestasis | 2 (1.8%) | 4 (4.0%) | |
| Graft failure | 3 (2.6%) | 2 (2.0%) | |
| Metabolic disease | 22 (19%) | 11 (11%) | |
| Primary liver malignancy | 14 (12%) | 6 (6.1%) | |
| Primary sclerosing cholangitis | 3 (2.6%) | 1 (1.0%) | |
| Other/unknown | 14 (12%) | 14 (14%) | |
| * Wilcoxon rank sum test; Pearson’s Chi-squared test; ** n (%); *** median (IQR). | |||