Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Jason Guo; Jorge A. Sanchez-Vivaldi; Madhukar S. Patel; Benjamin K. Wang; Andrew D. Shubin; Yash Kadakia; Jigesh A. Shah; Malcolm MacConmara; Steven Hanish; Parsia A. Vagefi; Christine S. Hwang

doi:10.12659/AOT.944245

06 August 2024 : Original article

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Jason Guo

^1ABCDEF, Jorge A. Sanchez-Vivaldi^23ABCDEF, Madhukar S. Patel^23ADE, Benjamin K. Wang^1ABC, Andrew D. Shubin^23ABCD, Yash Kadakia^1E, Jigesh A. Shah^23E, Malcolm MacConmara

^234DEF, Steven Hanish^23E, Parsia A. Vagefi^23E, Christine S. Hwang^23ACDEF*

DOI: 10.12659/AOT.944245

Ann Transplant 2024; 29:e944245

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Table 3 Outcomes of recipients of biopsied normal and abnormal livers.

Outcome characteristics	Biopsied normal liver (N=114)	Abnormal liver (N=99)	p-value*
Length of stay (d)^***	17 (11, 28.5)	18 (12, 32)	0.7
Rejection episode during admission^**	15 (13%)	9 (9.1%)	0.3
Treated for rejection within 6mo^**	20 (18%)	11 (11%)	0.2
Treated for rejection within 1yr^**	21 (18%)	16 (16%)	0.7
1-year graft survival^**	109 (96%)	93 (94%)	0.6
Graft failure cause^**
Primary non-function	1 (0.9%)	2 (2.0%)	0.6
Recurrent disease	0 (0.0%)	1 (1.0%)	0.5
Hepatic artery thrombosis	2 (1.8%)	1 (1.0%)	>0.9
Portal vein thrombosis	2 (1.8%)	0 (0.0%)	0.5
Other vascular thrombosis	2 (1.8%)	0 (0.0%)	0.5
Rejection chronic	1 (0.9%)	0 (0.0%)	>0.9
^* Wilcoxon rank sum test; Fisher’s exact test; Pearson’s Chi-squared test; ^ n (%); ^* median (IQR).

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Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

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