Risk Factors for Graft Failure After Penetrating Keratoplasty in Eastern China from 2018 to 2021

22 October 2024 : Original article

Yun Yang^123ABCDEFG, HongYa Zeng^123ABE, Lan Gong^123AB*, Tong Lin^123ABEG

DOI: 10.12659/AOT.945388

Ann Transplant 2024; 29:e945388

Introduction Material and Methods Results Discussion Conclusions References

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Table 3 Factors associated with early failure.

	N=502	Early failure (N=36)	n%	Base model		Multivariable model
	N=502	Early failure (N=36)	n%	OR (95% CI)	p value	OR (95% CI)	p value



Keratoconus	60	1	1.67%	1 (Ref)		1 (Ref)
Opacity	197	5	2.54%	1.58 (0.18–13.78)	0.7	2.32 (0.26–20.48)	0.45
Non-suppurative inflammation	63	10	15.87%	10.79 (1.33–87.37)	0.03	12.07 (1.49–97.75)
Suppurative inflammation	65	16	24.62%	17.10 (2.17–134.25)	0.01	13.56 (1.69–109.14)
Endothelial decompensation	52	1	1.92%	1.18 (0.07–19.50)	0.9	1.19 (0.07–19.63)	0.9
Burn	14	3	21.43%	13.88 (1.30–147.93)	0.03	18.11 (1.70–192.37)
Dystrophy or degeneration	51	0	0.00%	/	/	/	/

				3.45 (1.87–6.35) per 1 mm	0	2.40 (1.28–4.45) per 1 mm


≤2000	20	2	10.00%	0.76 (0.66–0.87) per 100 cells	0.05	0.85 (0.75–0.95) per 100 cells
2000–2250	39	9	23.08%
2250–2500	69	8	11.59%
2500–2750	140	8	5.71%
2750–3000	150	7	4.67%
>3000	84	2	2.38%


≤1	87	1	1.15%	1 (Ref)		1 (Ref)
2–30	98	6	6.12%	4.71 (0.55–40.23)	0.15	4.88 (0.48–49.43)	0.18
31–50	93	6	6.45%	4.50 (0.52–38.94)	0.17	0.45 (0.03–5.89)	0.54
51–70	173	18	10.40%	8.74 (0.86–66.95)	0.04	0.69 (0.06–8.12)	0.77
≥71	51	5	9.80%	7.66 (0.85–68.66)	0.07	1.01 (0.07–13.94)	0.95

No	288	16	5.56%	1 (Ref)		1 (Ref)
Yes (never surgically treated)	143	17	11.89%	2.36 (1.14–4.88)	0.02	1.33 (0.48–3.69)	0.58
Yes (surgically treated)	71	3	4.23%	0.76 (0.21–2.71)	0.67	0.64 (0.15–2.85)	0.59

Tn	423	26	6.15%	1 (Ref)		1 (Ref)
T+1	49	5	10.20%	1.70 (0.61–4.72)	0.31	1.56 (0.47–5.15)	0.47
T+2	25	5	20.00%	4.09 (1.40–11.97)	0.01	3.27 (0.91–11.65)	0.07
T+3	5	0	0.00%	/	/	/	/

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