24 December 2024 : Original article
Lung Transplant Success in COVID-19 Patients Requiring V-V ECMO: One-Year Follow-Up
Mazen F. Odish


DOI: 10.12659/AOT.946088
Ann Transplant 2024; 29:e946088
Table 1 Demographics and characteristics of patients with COVID-19 on V-V ECMO who received and did not receive lung transplantation. Data are n (%), median (IQR), n, or n/n (%) unless stated otherwise.
Patients with COVID-19 ARDS with lung transplantation | Patients with COVID-19 ARDS without lung transplantation | |
---|---|---|
n=9 | n=82 | |
Sex | ||
Female | 3 (33%) | 17 (21) |
Male | 6 (66%) | 65 (79) |
Age (years) | 48 (36–55) | 47 (38–54) |
Body mass index (kg/m) | 28.8 (23.1–30.3) | 31.8 (28.7–34.7) |
Blood group | ||
A | 2 (22%) | – |
B | 1 (11%) | – |
O | 6 (66%) | – |
AB | 0 (0%) | – |
Race | ||
White | 7 (77%) | 67 (81) |
Black | 0 (0%) | 2 (2) |
Asian | 2 (22%) | 6 (7) |
Native Pacific islander | 0 | 2 (2) |
More than 1 race | 0 | 4 (5) |
Hispanic ethnicity | 5 (56) | 60 (73) |
Vaccination status | ||
Unvaccinated | 8 (89%) | 65 (79) |
Vaccinated | 1 (11%) | 4 (5) |
Unknown | 0 | 13 (16) |
Treatment for COVID-19 | ||
Corticosteroids | 9 (100%) | 71 (87) |
Tocilizumab | 2 (22%) | 14 (17) |
Remdesivir | 5 (56%) | 62 (76) |
Baricitinib | 2 (22%) | 8 (10) |
Immunoglobulins | 0 (0%) | 1 (1) |
SOFA Score at ICU admission | 8.0 (6.0–8.0) | 8 (5.0–9.0) |
APACHE II Score at ICU admission | 23.0 (15.0–29.0) | – |
ECLS | ||
V-V ECMO (single dual-lumen cannula) | 3 (33) | 3 (4) |
V-V ECMO (2 cannulae) | 6 (66) | 78 (95) |
Second drainage cannula | 4 (44) | 4 (5) |
Length of support (days) | 57 (53–78) | 25 (14–44) |
ECLS Complications | ||
Air entrapment | 2 (22) | 0 (0) |
Hemorrhage (>3 units pRBC) | 8 (89) | 24 (29) |
Venous thromboembolism | 4 (44) | 14 (17) |
Cerebrovascular accident | 1 (11) | 15 (18) |
Seizure | 1 (11) | 2 (2) |
Cardiac arrest | 5 (55) | 8 (10) |
Limb amputation | 1 (11) | 3 (4) |
Renal replacement therapy | 1 (11) | 26 (32) |
Bacterial infection | 8 (89) | – |
Fungal infection | 3 (33) | – |
Survival to hospital discharge | 9 (100) | 36 (44) |
SOFA – sequential related organ failure assessment; APACHE – acute physiology and chronic health evaluation; ECLS – extracorporeal life support; V-V ECMO – veno-venous extracorporeal membrane oxygenation; pRBC – packed red blood cells. |