28 January 2025 : Original article
Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom Toxicity
Emilia Kruk
1ABCDEF*, Maciej Krasnodębski 1ACDE, Paweł Rykowski 1CDE, Wojciech Figiel 1BE, Wacław Hołówko 1BE, Joanna Raszeja-Wyszomirska 2BE, Michał Grąt 1BE
DOI: 10.12659/AOT.946485
Ann Transplant 2025; 30:e946485
Table 1 Comparisons between patients with acetaminophen- and A. phalloides-induced acute liver failure.
| Factor | Acetaminophen | A. phalloides | p value |
|---|---|---|---|
| Age of recipient (years) | 21 (19–33) | 49 (45–56) | |
| Sex (Female) | 14 (77.8%) | 10 (47.6%) | 0.053 |
| BMI | 24.9 (23.2–25.6) | 23.9 (22.0–28.7) | 0.727 |
| RBC (10/uL) | 3.6 (3.4–4.2) | 4.0 (3.3–4.4) | 0.535 |
| HGB (g/dL) | 11.6 (10.6–12.2) | 12.5 (10.4–13.8) | 0.284 |
| WBC (10/uL) | 9.4 (7.4–12.4) | 7.1 (5.4–13.3) | 0.209 |
| PLT (10/uL) | 121.0 (73.0–156.0) | 86.0 (58.0–157.0) | 0.612 |
| BILI (mg/dL) | 5.2 (3.7–8.4) | 5.8 (3.6–7.4) | 0.943 |
| CREA (mg/dL) | 0.9 (0.6–3.3) | 1.9 (1.1–2.3) | 0.242 |
| ALB (g/dL) | 2.8 (2.4–3.6) | 3.2 (2.6–3.5) | 0.854 |
| UREA (mg/dL) | 21.5 (15.0–60.0) | 45.0 (21.2–91.0) | 0.111 |
| AST (U/L) | 2555 (190–5886) | 4374 (624–8997) | 0.854 |
| ALT (U/L) | 5500 (2685–6858) | 3612 (1765–6916) | 0.602 |
| GGTP (U/L) | 76 (48–158) | 93 (53–223) | 0.693 |
| ALP (U/L) | 133 (98–159) | 122 (97–151) | 0.430 |
| LDH (U/L) | 3580 (520–5156) | 4095 (1965–8052) | 0.133 |
| INR | 4.4 (2.3–6.5) | 4.9 (3.4–6.9) | 0.642 |
| MELD Score | 36 (26–42) | 34 (29–41) | 0.662 |
| Patient within King’s College Criteria | 8 (57.14%) | 14 (66.66%) | 0.443 |
| Renal failure requiring hemodialysis in perioperative period | 9 (52.94%) | 10 (55.56%) | 0.500 |
| Days on transplant waitlist | 1.0 (1.0–2.0) | 1.0 (1.0–3.0) | 0.789 |
| RBC units transfused intraoperatively | 3.0 (2.0–4.0) | 6.0 (4.5–11.0) | |
| FFP units transfused intraoperatively | 6.0 (3.0–8.0) | 9.5 (7.0–16.0) | |
| End-to-end vena cava anastomosis | 14 (77.8%) | 10 (47.6%) | 0.054 |
| Age of donor (years) | 43 (33–59) | 47 (39–56) | 0.988 |
| DRI (Feng et al) | 1.4 (1.2–1.8) | 1.3 (1.2–1.7) | 0.488 |
| Liver AB0 compatible | 15 (83.3%) | 14 (66.7%) | 0.207 |
| CIT (hours) | 8.5 (7.0–9.0) | 7.6 (7.1–9.0) | 0.635 |
| Graft loss | 7 (38.9%) | 11 (52.4%) | 0.284 |
| Death within 90-day post-LT | 4 (22.2%) | 8 (38.1%) | 0.399 |
| ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BILI – bilirubin; BMI – body mass index; CI – confidence interval; CIT – cold ischemia time; CREA – creatinine; DRI – donor risk index; FFP – fresh frozen plasma; GGTP – gamma-glutamyl transferase; HGB – hemoglobin; INR – international normalized ratio; LDH – lactate dehydrogenase; LT – liver transplantation; MELD Score– Model for End-Stage Liver Disease Score; OR – odds ratio; PLT – platelet; RBC – red blood cell count; WBC – white blood cell count. | |||