28 January 2025 : Original article
Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom Toxicity
Emilia Kruk
1ABCDEF*, Maciej Krasnodębski 1ACDE, Paweł Rykowski 1CDE, Wojciech Figiel 1BE, Wacław Hołówko 1BE, Joanna Raszeja-Wyszomirska 2BE, Michał Grąt 1BE
DOI: 10.12659/AOT.946485
Ann Transplant 2025; 30:e946485
Table 2 Association of selected factors with 90-day mortality.
| Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| poisoning | 2.154 (0.522–8.892) | 0.229 | ||
| Acetaminophen poisoning | 0.464 (0.112–1.917) | 0.289 | ||
| Sex (Female) | 0.500 (0.125–1.999) | 0.327 | ||
| Age of recipient (years) | 1.020 (0.979–1.064) | 0.345 | ||
| BMI | 1.146 (0.896–1.467) | 0.278 | ||
| HGB (g/dL) | 0.728 (0.527–1.007) | 0.055 | ||
| PLT count (10/uL) | 0.990 (0.978–1.003) | 0.128 | ||
| BILI (mg/dL) | 1.191 (0.988–1.435) | 0.066 | ||
| CREA (mg/dL) | 1.184 (0.850–1.650) | 0.317 | ||
| ALB (g/dL) (lower concentration) | 4.281 (1.273–14.397) | 0.950 | ||
| AST (U/L)* | 0.989 (0.971–1.007) | 0.237 | ||
| ALT (U/L) (lower activity)* | 1.029 (1.003–1.056) | 0.911 | ||
| LDH (U/L) | 0.985 (0.964–1.006) | 0.159 | ||
| INR | 0.970 (0.742–1.268) | 0.825 | ||
| MELD Score | 1.065 (0.978–1.159) | 0.148 | ||
| Patient within King’s College Criteria | 1.905 (0.402–9.023) | 0.417 | ||
| Renal failure requiring hemodialysis in perioperative period | 13.500 (1.473–123.748) | 0.586 | ||
| Days on transplant waitlist | 2.289 (1.189–4.406) | 0.058 | ||
| RBC units transfused intraoperatively | 1.574 (1.112–2.228) | 1.609 (1.119–2.314) | ||
| FFP units transfused intraoperatively | 1.346 (1.104–1.640) | 0.773 | ||
| End-to-end vena cava anastomosis | 0.824 (0.205–3.301) | 0.784 | ||
| Age of donor (years) | 1.012 (0.962–1.065) | 0.639 | ||
| DRI (Feng et al) | 2.709 (0.167–43.822) | 0.483 | ||
| Liver AB0 incompatible | 1.750 (0.389–7.879) | 0.466 | ||
| CIT (hours) | 1.296 (0.862–1.950) | 0.213 | ||
| ALB – albumin; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BILI – bilirubin; BMI – body mass index; CI – confidence interval; CIT – cold ischemia time; CREA – creatinine; DRI – donor risk index; FFP – fresh frozen plasma; HGB – hemoglobin; INR – international normalized ratio; LDH – lactate dehydrogenase; MELD Score– Model for End-Stage Liver Disease Score; OR – odds ratio; PLT – platelet; RBC – red blood cell count. * ALT and AST activity values were analyzed after division of the value by 100. | ||||