14 April 2026 : Original article
Incidence, Clinical Features, and Risk Factors of Early Neurological Complications After Orthotopic Liver Transplantation: A Single-Center Experience
Federica Avorio
ABDEF 1*, Giovanna Russelli B 2, Rossella Alduino BC 2, Giovanna Panarello BD 3, Alessio Provenzani DF 4, Antonio Arcadipane AE 3, Salvatore Gruttadauria ADE 5,6, Vincenzina Lo Re ADEFG 1
DOI: 10.12659/AOT.946854
Ann Transplant 2026; 31:e946854
Table 2 Hepatic disease etiology in patients with and without neurological complications.
| Hepatic disease etiology | NC# (%) | nNC# (%) | total | p | OR |
|---|---|---|---|---|---|
| 0.0405 | 0.61 | ||||
| Yes | 39 (10.4) | 146 (38.8) | 185 (49.2) | ||
| No | 58 (15.4) | 133 (35.4) | 191 (50.8) | ||
| HCV eradication | 0.0885 | – | |||
| Yes | 7 (1.9) | 45 (12) | 52 (13.9) | ||
| No | 33 (8.8) | 98 (26.1) | 131 (34.9) | ||
| 0.1729 | – | ||||
| Yes | 44 (11.7) | 149 (39.6) | 193 (51.3) | ||
| No | 53 (14.1) | 130 (34.6) | 183 (48.7) | ||
| 0.5414 | – | ||||
| Yes | 31 (8.2) | 80 (21.3) | 111 (29.5) | ||
| No | 66 (17.6) | 199 (52.9) | 265 (70.5) | ||
| 0.6532 | – | ||||
| Yes | 15 (4) | 15 (4) | 30 (8) | ||
| No | 82 (21.8) | 241 (64.1) | 323 (85.9) | ||
| 0.5967 | – | ||||
| Yes | 7 (1.9) | 25 (6.7) | 32 (8.5) | ||
| No | 90 (23.9) | 254 (67.5) | 344 (91.5) | ||
| Yes | 28 (7.5) | 113 (30.1) | 141 (37.5) | ||
| No | 69 (18.4) | 166 (44.2) | 235 (62.5) | ||
| 0.5662 | – | ||||
| Yes | 11 (2.9) | 38 (10.1) | 49 (13) | ||
| No | 86 (22.9) | 241 (64.1) | 327 (87) | ||
| 0.2879 | – | ||||
| Yes | 2 (0.5) | 2 (0.5) | 4 (1.1) | ||
| No | 95 (25.3) | 277 (73.7) | 372 (98.9) | ||
| 0.8043 | – | ||||
| Yes | 2 (0.5) | 7 (1.9) | 9 (2.4) | ||
| No | 95 (25.3) | 272 (72.3) | 367 (97.6) | ||
| 0.8572 | – | ||||
| Yes | 10 (2.7) | 27 (7.2) | 37 (9.8) | ||
| No | 87 (23.1) | 252 (67) | 339 (90.2) | ||
| 0.1309 | – | ||||
| Yes | 10 (2.7) | 16 (4.2) | 26 (6.9) | ||
| No | 87 (23.1) | 263 (70) | 350 (93.1) | ||
| Yes | 17 (4.5) | 24 (6.4) | 41 (10.9) | ||
| No | 80 (21.3) | 255 (67.8) | 335 (89.1) | ||
| A generic viral etiology of cirrhosis and HCV etiology appeared to be protective against NC onset after liver transplant. Being in a critical condition before surgery was significantly associated with developing NCs after OLT. HBV – hepatitis B virus; HCC – hepatocarcinoma; HCV – hepatitis C virus; NASH – non-alcoholic steatohepatitis; NCs – neurological complications; nNCs – non-neurological complications; OR – odds ratio. | |||||