14 April 2026 : Original article
Incidence, Clinical Features, and Risk Factors of Early Neurological Complications After Orthotopic Liver Transplantation: A Single-Center Experience
Federica Avorio
ABDEF 1*, Giovanna Russelli B 2, Rossella Alduino BC 2, Giovanna Panarello BD 3, Alessio Provenzani DF 4, Antonio Arcadipane AE 3, Salvatore Gruttadauria ADE 5,6, Vincenzina Lo Re ADEFG 1
DOI: 10.12659/AOT.946854
Ann Transplant 2026; 31:e946854
Table 3 Clinical, instrumental, and prognostic details of NCs.
| NC | n (%) |
|---|---|
| 97 | |
| 125 | |
| 53 (14.1) | |
| 14 (3.7) | |
| 14 (3.7) | |
| 11 (2.9) | |
| 11 (2.9) | |
| 5 (1.3) | |
| 4 (1.1) | |
| 4 (1.1) | |
| 1 (0.3) | |
| 8 (2.1) | |
| 97 | |
| 40 | |
| Normal | 9 |
| Minor EEG abnormalities | 26 |
| Major EEG abnormalities | 4 |
| 57 | |
| CT/MRI abnormalities | 27 |
| 24 | |
| FK dose reduction | 4 |
| FK withheld | 20 |
| None or minor | 77 |
| Severe | 11 |
| Death because of NC | 9 |
| The most frequent was delirium/metabolic encephalopathy followed by seizures and clinical manifestations of neurotoxicity. Percentages were calculated on the total of 376 enrolled patients. N – number; NCs – neurological complications; ODS – osmotic demyelinating syndrome; PNS – peripheral nervous system; CNS – central nervous system; EEG – electroencephalogram; CT – computed tomography; MRI – magnetic resonance imaging; FK – tacrolimus. | |