14 April 2026 : Original article
Incidence, Clinical Features, and Risk Factors of Early Neurological Complications After Orthotopic Liver Transplantation: A Single-Center Experience
Federica Avorio
ABDEF 1*, Giovanna Russelli B 2, Rossella Alduino BC 2, Giovanna Panarello BD 3, Alessio Provenzani DF 4, Antonio Arcadipane AE 3, Salvatore Gruttadauria ADE 5,6, Vincenzina Lo Re ADEFG 1
DOI: 10.12659/AOT.946854
Ann Transplant 2026; 31:e946854
Table 4 Perioperative variables in patients with and without neurological complications.
| Perioperative variables | nNC | NC | p | OR |
|---|---|---|---|---|
| 146 | 146 | 0.9694 | – | |
| 143 | 144 | |||
| 7 | 8 | 0.1069 | – | |
| 4 | 6 | |||
| 2.1 | 2 | 0.4402 | – | |
| 2.3 | 2.3 | 0.6734 | – | |
| 390 | 405 | 0.1621 | – | |
| 45 | 45 | 0.3801 | – | |
| 5* | 5* | 0.2371 | – | |
| 5** | 5** | 0.3096 | – | |
| 103 (27.4) | 41 (10.9) | 0.091 | – | |
| 56 (14.9) | 47 (12.5) | |||
| 13 (3.5) | 25 (6.7) | |||
| 129 (34.3) | 77 (20.5) | |||
| 21 (5.6) | 20 (5.3) | |||
| 107 (28.5) | 71 (18.9) | |||
| 10 (2.7) | 4 (1.1) | 0.8091 | – | |
| 19 (5) | 18 (4.8) | 0.943 | – | |
| 26 (6.9) | 5 (1.3) | 0.2028 | – | |
| 76 (20.2) | 21 (5.6) | 0.1925 | – | |
| 2 (72.9) | 96 (25.5) | 0.7642 | – | |
| Postoperative acute renal disease, need for CRRT, postoperative infections, rejection, having more than 3 postoperative complications, higher plasma concentration of Na at POD 2 and higher delta Na (preoperative to POD 2) were correlated with higher risk of developing early NCs after OLT. * Calculated on 105 patients; ** calculated on 103 patients. CRRT – continuous renal replacement therapy; IS – immunosuppression; FK – tacrolimus; Na – sodium; NCs – neurological complications; nNCs – non-neurological complications; OR – odds ratio; PO – postoperative; CIT – cold ischemia time; Mg – magnesium; pre-op – preoperative; POD – postoperative day; WIT – warm ischemia time. | ||||