Steroid Use in ABO-Incompatible Kidney Transplants: Withdrawal vs Maintenance

29 July 2025 : Original article

Dong Hui Shin

^{BCDEF 1}, Ji Teak Kim^{DE 2}, Sung Hwa Kim^{C 3}, Keunryeol Park

^{B 1}, Deok Gie Kim

^{ABCE 4*}, Jun Young Lee

^{ABCDEFG 1}

DOI: 10.12659/AOT.947747

Ann Transplant 2025; 30:e947747

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Table 2 Baseline characteristics.

Variable	Steroid maintain (n=13)	Rapid steroid withdrawal (n=6)	P value
Age (years)	46.9±15.8	48.2±13.5	0.870
Sex, male	9 (69.2)	2 (33.3)	0.141
BMI (kg/m)	24.8±5.1	22.1±3.5	0.263
Year of KT			0.200
2014–2017	3 (23.1)	0 (0.0)
2018–2021	10 (76.9)	6 (100)
Re-transplantation	0 (0.0)	0 (0.0)
Cause of ESKD			0.811
DM	5 (38.5)	2 (33.3)
Hypertension	1 (7.7)	1 (16.7)
Glomerular disease	5 (38.5)	1 (16.7)
PCKD	1 (7.7)	1 (16.7)
Unknown	1 (7.7)	1 (16.7)
Dialysis duration (months)	7.7±12.3	30.8±46.7	0.106
DM	5 (38.5)	2 (33.3)	0.829
CVD	0 (0.0)	0 (0.0)
Donor type			0.499
Parent	3 (23.1)	2 (33.3)
Offspring	3 (23.1)	1 (16.7)
Sibling	0 (0.0)	1 (16.7)
Spouse	5 (38.5)	2 (28.6)
Other unrelated	2 (15.4)	0 (0.0)
Donor age (years)	48.6±13.2	53.5±12.9	0.460
Donor sex, male	9 (69.2)	5 (83.3)	0.516
Donor BMI (kg/m)	26.7±4.4	26.2±3.0	0.788
Donor creatinine at donation (mg/dL)	0.98±0.30	0.90±0.21	0.555
Donor HTN	2 (15.4)	2 (33.3)	0.372
Donor DM	1 (7.7)	1 (16.7)	0.554
CIT (min)	72.1±18.4	73.3±15.4	0.886
HLA mismatch	4.0±1.2	3.3±0.8	0.244
Induction agent			0.077
IL-2 receptor antibody	8 (61.5)	6 (100)
Anti-thymocyte globulin	5 (38.5)	0 (0.0)
Prescription of valganciclovir at discharge	8 (61.5)	0 (0.0)	0.012
Data are expressed as mean±standard deviation or number (%). BMI – body mass index; CIT – cold ischemic time; CVD – cardiovascular disease; DM – diabetes mellitus; ESKD – end-stage kidney disease; HLA – human leukocyte antigens; HTN – hypertension – KT – kidney transplant; PCKD – polycystic kidney disease.

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