16 September 2025 : Original article
Effect of Recipient Variables on Transplant Survival Following Marginal Kidney Donation: Analysis of a Mate Kidney Cohort
Ariadni Androvitsanea ABCDEF 1,2*, Katharina M. Heller AB 1, Hendrik Apel BD 3, Frank Kunath
BD 3, Peter J. Goebell E 3, Bernd Wullich BDF 3, Ulrich Rother EF 4, Christoph Daniel BCDE 5, Kerstin Amann ABCD 5, Carsten Willam ABCDEG 1, Mario Schiffer ADE 1
DOI: 10.12659/AOT.948739
Ann Transplant 2025; 30:e948739
Table 4 Factors associated with graft survival.
| N (Number of patients) | 85 | 85 | P (Statistical significance)1 | Total N=170 |
|---|---|---|---|---|
| At least 1 episode of graft rejection | 0.877 | |||
| No rejection | 52.4% (44) | 50% (42) | 51.2% (86) | |
| Rejection | 47.6% (40) | 50% (42) | 48.8% (82) | |
| Mean recipient age±SD (years) | 57.09±14.99 | 59.21±10.60 | 0.730 | 58.15±12.99 |
| Cold ischemia time in hours (Mean±SD) | 11.89±5.01 | 12.07±4.48 | 0.967 | 11.98±4.74 |
| Secondary warm ischemia time (minutes) | 43.22±20.25 | 45.71±19.30 | 0.200 | 44.46±19.76 |
| Cardiovascular disease (CVD) | 0.503 | |||
| w/o CVD | 72.9% (62) | 67.1% (57) | 70% (119) | |
| CVD | 27.1% (23) | 32.9% (28) | 30% (51) | |
| Recipient BMI (kg/m) | 25.05±3.69 | 26.21±4.17 | 0.170 | 25.63±3.97 |
| Diabetes mellitus (DM) | 0.844 | |||
| w/o DM | 82.4% (70) | 80% (68) | 81.2% (138) | |
| DM | 17.6% (15) | 20% (17) | 19.3% (32) | |
| Acute tubular injury (ATI) in pre-transplant biopsy | 0.307 | |||
| Non-severe ATI | 83.8% (62) | 75.7% (56) | 79.7% (118) | |
| Severe ATI | 16.2% (12) | 24.3% (18) | 20.3% (30) | |
| Primary function | 0.104 | |||
| Primary function | 72.9% (62) | 60.0% (51) | 66.5% (113) | |
| Delayed graft function or permanent non-function | 27.1% (23) | 40.0% (34) | 33.5% (57) | |
| Creatinine 1 month after kidney transplantation (mg/dl) | 2.04±0.91 | 1.98±1.28 | 0.779 | 2.00±1.12 |
| Creatinine 1 year after kidney transplantation (mg/dl) | 1.57±0.71 | 1.46±1.12 | 0.443 | 1.51±0.93 |
| 1 p calculated with the paired Wilcoxon signed-rank test for numerical variables, Chi-square test used for nominal variables. | ||||