16 September 2025 : Original article
Effect of Recipient Variables on Transplant Survival Following Marginal Kidney Donation: Analysis of a Mate Kidney Cohort
Ariadni Androvitsanea ABCDEF 1,2*, Katharina M. Heller AB 1, Hendrik Apel BD 3, Frank Kunath
BD 3, Peter J. Goebell E 3, Bernd Wullich BDF 3, Ulrich Rother EF 4, Christoph Daniel BCDE 5, Kerstin Amann ABCD 5, Carsten Willam ABCDEG 1, Mario Schiffer ADE 1
DOI: 10.12659/AOT.948739
Ann Transplant 2025; 30:e948739
Table 5 The effect of cold ischemia time.
| N (number of patients) | 97 | 97 | P (Statistical significance)1 | Total N=194 |
|---|---|---|---|---|
| Mean Time on dialysis±SD (months before transplantation) | 60.32±37.28 | 61.74±36.28 | 0.970 | 61.03±36.69 |
| At least 1 episode of graft rejection | 0.885 | |||
| No rejection episode | 52.1% (50) | 54.2% (52) | 53.1% (102) | |
| Rejection episode(s) | 47.9% (46) | 45.8% (44) | 46.9% (90) | |
| Mean survival time±SD (months) | 82.85±49.92 | 74.88±49.40 | 0.269 | 78.86±49.69 |
| Cardiovascular disease (CVD) | 0.519 | |||
| w/o CVD | 75.3% (73) | 70.1% (68) | 72.7% (141) | |
| CVD | 24.7% (24) | 29.9% (29) | 27.3% (53) | |
| Recipient BMI (kg/m) | 25.49±4.00 | 25.73±4.01 | 0.914 | 25.61±4.00 |
| Diabetes mellitus (DM) | 0.844 | |||
| w/o DM | 81.4% (79) | 82.5% (80) | 82% (159) | |
| DM | 18.6% (18) | 17.5% (17) | 18% (35) | |
| Secondary warm ischemia time (minutes) | 44.75±20.61 | 43.68±19.50 | 0.573 | 44.22±20.02 |
| Acute tubular injury (ATI) in pre-transplant biopsy | 1.0 | |||
| Non-severe ATI | 78.6% (66) | 78.6 (66) | 78.6% (132) | |
| Severe ATI | 21.4% (18) | 21.4% (18) | 21.4% (36) | |
| Primary function | 0.880 | |||
| Primary function | 63.9% (62) | 66.0% (64) | 64.9% (126) | |
| Delayed graft function or permanent non-function | 36.1% (35) | 34.0% (33) | 35.1% (68) | |
| Creatinine 1 month after kidney transplantation (mg/dl) | 2.08±1.12 | 1.99±1.10 | 0.996 | 2.03±1.11 |
| Creatinine 1 year after kidney transplantation (mg/dl) | 1.49±0.93 | 1.54±0.97 | 0.667 | 1.52±0.95 |
| 1 p calculated with the paired Wilcoxon signed-rank test for numerical variables; Chi-square test used for nominal variables. | ||||