02 September 2025 : Original article
New-Onset Diabetes After Liver Transplantation: An SRTR Database Study of Incidence and Risk Factors
Saxiao Tang AEF 1,2, Shengmin Mei BCD 1, Shichao Shen
BCF 2, Li Wang BCF 2, Yue Wu CDF 2, Jie Xiang ACF 1,2, Zhiwei Li ACDG 1,2*
DOI: 10.12659/AOT.949062
Ann Transplant 2025; 30:e949062
Table 2 Donor characteristics.
| NODAT (n=2973) | Non-NODAT (n=36855) | P | |
|---|---|---|---|
| Age: years (SD) | 42±16 | 41±16 | 0.492 |
| BMI: kg/m (SD) | 27.9±6.6 | 28.0±6.6 | 0.913 |
| Male/Female | 1737/1236 | 22041/14814 | 0.145 |
| LDLT/DDLT | 118/2855 | 2066/34789 | <0.001 |
| Race (%) | |||
| Caucasian | 1861 (62.6) | 24043 (65.2) | 0.004 |
| African-American | 538 (18.1) | 6589 (17.9) | 0.767 |
| Hispanic | 456 (15.3) | 4896 (13.3) | 0.002 |
| Asian | 75 (2.5) | 894 (2.4) | 0.717 |
| Others | 43 (1.4) | 433 (1.2) | 0.186 |
| Cause of death (%) | |||
| Anoxia | 1045 (35.1) | 14048 (38.1) | 0.001 |
| CVA/stroke | 906 (30.5) | 10181 (27.6) | 0.001 |
| Head trauma | 836 (28.1) | 9738 (26.4) | 0.044 |
| Others | 186 (6.3) | 2886 (7.8) | 0.002 |
| Last creatinine: mg/dl (SD) | 1.79±1.92 | 1.78±1.89 | 0.655 |
| Last AST: U/L (SD) | 90±157 | 85±164 | 0.152 |
| WIT: minutes (SD) | 20.2±23.8 | 12.7±20.1 | <0.001 |
| CIT: hours (SD) | 6.0±2.3 | 5.7±2.4 | <0.001 |
| Diabetes (%) | 400 (13.5) | 4343 (11.8) | 0.007 |
| Hypertension (%) | 1056 (35.5) | 12370 (33.6) | 0.031 |
| DRI (SD) | 1.41±0.36 | 1.44±0.36 | 0.016 |
| NODAT – new-onset diabetes after transplantation; SD – standard deviation; BMI – body mass index; LDLT – living donor liver transplantation; DDLT – deceased donor liver transplantation; CVA – cerebrovascular accident; WIT – warm ischemia time; CIT – cold ischemia time; AST – aspartate aminotransferase; DRI – donor risk index. | |||