New-Onset Diabetes After Liver Transplantation: An SRTR Database Study of Incidence and Risk Factors

02 September 2025 : Original article

Saxiao Tang^{AEF 1,2}, Shengmin Mei^{BCD 1}, Shichao Shen

^{BCF 2}, Li Wang^{BCF 2}, Yue Wu^{CDF 2}, Jie Xiang^{ACF 1,2}, Zhiwei Li

^{ACDG 1,2*}

DOI: 10.12659/AOT.949062

Ann Transplant 2025; 30:e949062

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Table 3 Estimated risk factors for NODAT occurrence according to univariable and multivariable logistic regression analyses.

	Univariable model			Multivariable model
	OR	95% CI	p	OR	95% CI	P
Recipient age (≤50 years)	0.79	0.73–0.86	<0.001	0.78	0.69–0.89	<0.001
Male recipients	1.19	1.09–1.28	<0.001	1.21	1.07–1.34	0.002
Recipient BMI (≤25 kg/m)	0.84	0.77–0.91	<0.001	0.84	0.75–0.94	0.003
MELD	1.00	0.99–1.01	0.446	1.01	0.99–1.02	0.076
Pre-transplant medical condition (in hospital)	1.00	0.93–1.09	0.920	0.98	0.84–1.14	0.795
HLA mismatch ≥3	1.05	0.97–1.14	0.226	1.05	0.94–1.17	0.424
CMV infection	1.15	1.06–1.25	<0.001	1.13	1.01–1.26	0.033
Acute rejection episodes	1.10	0.93–1.30	0.283	1.24	0.97–1.58	0.088
Immuno-induction therapy	1.08	0.99–1.16	0.052	0.96	0.86–1.07	0.472
Steroids used at discharge	1.88	1.70–2.09	<0.001	1.81	1.55–2.12	<0.001
TAC used at discharge	1.52	1.26–1.82	<0.001	1.47	1.21–1.77	<0.001
Donor age (≤60 years)	0.96	0.86–1.08	0.507	0.87	0.73–1.04	0.119
LDLT	0.70	0.58–0.84	<0.001	0.80	0.65–0.99	0.035
Male donor	0.95	0.88–1.02	0.140	0.89	0.80–0.99	0.039
Donor BMI (≤25 kg/m)	1.03	0.95–1.11	0.539	1.06	0.95–1.19	0.273
CIT	1.03	1.01–1.04	<0.001	1.00	0.98–1.02	0.858
WIT	1.01	1.01–1.02	<0.001	1.01	1.01–1.02	<0.001
Donor with diabetes	1.16	1.04–1.30	0.007	1.22	1.05–1.42	0.012
OR – odds ratio; CI – confidence interval; BMI – body mass index; MELD – model for end-stage liver disease; HLA – human leukocyte antigen; CMV – cytomegalovirus; TAC – tacrolimus; LDLT – living donor liver transplantation; CIT – cold ischemia time; WIT – warm ischemia time.

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