New-Onset Diabetes After Liver Transplantation: An SRTR Database Study of Incidence and Risk Factors

02 September 2025 : Original article

Saxiao Tang^{AEF 1,2}, Shengmin Mei^{BCD 1}, Shichao Shen

^{BCF 2}, Li Wang^{BCF 2}, Yue Wu^{CDF 2}, Jie Xiang^{ACF 1,2}, Zhiwei Li

^{ACDG 1,2*}

DOI: 10.12659/AOT.949062

Ann Transplant 2025; 30:e949062

Authors information Article notes Copyright and License information

Introduction Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 4 Univariable and multivariable Cox regression analyses of risk factors for graft failure.

	Univariable model			Multivariable model
	HR	95% CI	p	HR	95% CI	P
NODAT	1.15	1.04–1.26	0.005	1.28	1.10–1.48	<0.001
Recipient age (≤50 years)	0.92	0.87–0.98	0.006	1.03	0.94–1.14	0.533
Male recipient	1.12	1.05–1.18	<0.001	1.13	1.02–1.24	0.014
Recipient BMI (≤25 kg/m)	1.13	1.06–1.19	<0.001	1.07	0.98–1.17	0.149
MELD	0.99	0.98–0.99	0.003	0.99	0.98–0.99	0.012
Pre-transplant medical condition (in hospital)	1.00	0.95–1.06	0.991	1.00	0.89–1.14	0.948
Previous abdominal surgery	1.11	1.05–1.17	<0.001	1.06	0.97–1.15	0.223
HLA mismatch ≥3	1.03	0.97–1.09	0.299	0.97	0.88–1.06	0.459
CMV infection	0.97	0.92–1.03	0.294	1.04	0.95–1.13	0.422
EBV infection	1.03	0.94–1.14	0.518	1.10	0.96–1.26	0.167
Acute rejection episodes	1.32	1.18–1.49	<0.001	1.19	0.98–1.45	0.077
Hospital stay	1.01	1.01–1.02	<0.001	1.01	1.01–1.02	<0.001
Immuno-induction therapy	1.06	1.00–1.12	0.047	1.09	0.99–1.20	0.086
Steroids used at discharge	0.99	0.93–1.06	0.862	1.09	0.97–1.22	0.165
TAC used at discharge	0.50	0.46–0.55	<0.001	0.61	0.52–0.71	<0.001
Donor age (≤60 years)	0.74	0.69–0.79	<0.001	0.91	0.80–1.04	0.175
Male donor	0.99	0.94–1.05	0.838	1.10	1.01–1.20	0.032
Donor BMI (≤25 kg/m)	0.98	0.93–1.04	0.546	1.02	0.93–1.11	0.754
CIT	1.01	0.99–1.02	0.102	1.00	0.98–1.02	0.902
WIT	1.00	0.99–1.01	0.259	1.00	0.99–1.01	0.973
Donor with diabetes	1.26	1.17–1.36	<0.001	1.08	0.95–1.23	0.299
Donor with hypertension	1.25	1.18–1.32	<0.001	1.02	0.92–1.12	0.763
DRI	1.66	1.54–1.78	<0.001	1.66	1.45–1.90	<0.001
HR – hazard ratio; CI – confidence interval; NODAT – new-onset diabetes after transplantation.

Back to the Article