30 September 2025 : Original article
Post-Transplant Outcomes in Patients with Previously Treated Extrahepatic Malignancies Undergoing Living Donor Liver Transplantation
Amy Kim
BDEF 1, Shin Hwang ABCDEF 1*, Chul-Soo Ahn BDE 1, Deok-Bog Moon BCE 1, Tae-Yong Ha BCD 1, Gi-Won Song BCDF 1, Dong-Hwan Jung BCF 1, Gil-Chun Park BCD 1, Woo-Hyoung Kang BCD 1, Young-In Yoon BCD 1, Sung-Gyu Lee AEF 1
DOI: 10.12659/AOT.949461
Ann Transplant 2025; 30:e949461
Table 2 Profiles of patients treated for uncommon extrahepatic malignancies before living donor liver transplantation.
| Patient No. | Diagnosis | Interval between EHM treatment and LT | EHM tumor stage | EHM treatment | EHM tumor recurrence | Interval between LT and EHM recurrence | De novo malignancies after LT | Survival outcome |
|---|---|---|---|---|---|---|---|---|
| 1 | Pharyngeal cancer | 6 months | Stage I | Surgery, Radiotherapy | No | N/A | No | Died after 4 years due to HCC recurrence |
| 2 | Pharyngeal cancer | 13 years | Stage I | Surgery, Radiotherapy | No | N/A | No | Alive for 10 years |
| 3 | Bladder cancer | 2 years | Stage I | Surgery | No | N/A | No | Alive for 4 years |
| 4 | Bladder cancer | 10 years | Stage 0 | Surgery | No | N/A | No | Alive for 8 years |
| 5 | Skin basal cell cancer | 4 years | Stage I | Surgery | No | N/A | No | Alive for 13 years |
| 6 | Common bile duct cancer | 4 years | Stage IB | Surgery, Chemotherapy | No | N/A | No | Alive for 25 years |
| 7 | Gallbladder cancer | 7 years | Stage IB | Surgery | No | N/A | Penectomy due to penis melanoma 6 years after LT | Alive for 9 years |
| 8 | Supraglottic cancer | 1 year | Stage III | Surgery, Chemo-radiotherapy | No | N/A | No | Died after 2 years due to HCC recurrence |
| 9 | Esophageal cancer | 4 years | Stage I | Endoscopic mucosal resection | No | N/A | No | Died after 4 months due to HCC recurrence |
| 10 | Ovarian cancer | 23 years | Stage I | Surgery | No | N/A | No | Alive for 24 years |
| 11 | Thymus cancer | 2 years | Stage I | Surgery | No | N/A | No | Alive for 14 years |
| EHM – extrahepatic malignancy; LT – liver transplantation; HCC – hepatocellular carcinoma; N/A – not available. | ||||||||