26 August 2025 : Original article
Association of HLA Alleles with IgA Nephropathy and Its Recurrence After Kidney Transplantation
Karol Graňák DEF 1,2, Matej Vnučák
A 1,2*, Patrícia Kleinová B 1,2, Tímea Blichová B 1,2, Andrej Kollár B 1,2, Andrej Čereš AD 3, Ivana Dedinská AC 4,5
DOI: 10.12659/AOT.949689
Ann Transplant 2025; 30:e949689
Table 1 Comparison of HLA-DRB and -DQB alleles between the IgAN group and the control group.
| HLA allele | Frequency IgAN group | IgAN group (n=48) | Control group (10 000 White donors) | OR | P value |
|---|---|---|---|---|---|
| DRB1*11 | 23x | 47.92% | 22.98% | 2.09 | 0.0048 |
| DRB1*04 | 16x | 33.33% | 24.58% | 1.33 | 0.3061 |
| DRB1*15 | 11x | 22.92% | 24.93% | 0.92 | 0.8778 |
| DRB1*07 | 10x | 20.83% | 22.61% | 0.91 | 0.8932 |
| DRB1*13 | 7x | 14.58% | 24.57% | 0.58 | 0.5397 |
| DRB1*03 | 2x | 4.17% | 21.73% | 0.2 | 0.5472 |
| DQB1*03 | 32x | 66.00% | 55.58% | 1.19 | 0.2368 |
| DQB1*06 | 14x | 29.17% | 43.89% | 0.67 | 0.2678 |
| DQB1*05 | 11x | 22.92% | 32.96% | 0.69 | 0.4794 |
| DQB1*02 | 8x | 16.67% | 36.39% | 0.47 | 0.2468 |
| DQB1*04 | 4x | 8.33% | 6.27% | 1.33 | 0.8605 |
| HLA – human leukocyte antigen; IgAN – immunoglobulin A nephropathy. | |||||