Association of HLA Alleles with IgA Nephropathy and Its Recurrence After Kidney Transplantation

26 August 2025 : Original article

Karol Graňák^{DEF 1,2}, Matej Vnučák

^{A 1,2*}, Patrícia Kleinová^{B 1,2}, Tímea Blichová

^{B 1,2}, Andrej Kollár

^{B 1,2}, Andrej Čereš^{AD 3}, Ivana Dedinská^{AC 4,5}

DOI: 10.12659/AOT.949689

Ann Transplant 2025; 30:e949689

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Table 2 HLA alleles and the risk of IgAN recurrence in Cox regression hazard model.

Endpoint:	IgAN recurrence after KT
HLA allele	Hazard ratio	95% CI	P value
DRB1*11	2.3967	0.3190–8.0060	0.3956
DRB1*04	0.8360	0.1183–5.9076	0.8575
DRB1*15	0.3709	0.0336–4.0911	0.4181
DRB1*07	3.1398	0.2942–6.5115	0.3436
DRB1*13	1.1267	0.7199–2.8802	0.9588
DRB1*03	1.8838	0.1556–3.8091	0.6187
DQB1*03	0.6826	0.0523–8.9146	0.7709
DQB1*06	0.6519	0.0705–6.0266	0.7061
DQB1*05	2.0586	0.2803–5.1209	0.4779
DQB1*02	0.1955	0.0189–2.0203	0.9583
DQB1*04	5.5890	0.7688–8.6290	0.0891
HLA – human leukocyte antigen; IgAN – immunoglobulin A nephropathy; KT – kidney transplantation.

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