10 February 2026 : Original article
Inferior Long-Term Outcome of Fatty Liver Allografts After Orthotopic Liver Transplantation
Svenja Krause BDEF 1, Helena Maria Linge CE 1, Ulrich Zwirner
BE 1, Alexander Wagner BE 1, Nicolas Richter BDE 1, Moritz Schmelzle ADE 1, Ulf Kulik ABCDEF 1*
DOI: 10.12659/AOT.950589
Ann Transplant 2026; 31:e950589
Table 2 Results of univariable and multivariable Cox regression analyses regarding influence on survival, with hazard ratios (HR).
| Variable | Univariable Cox regression | Multivariable Cox regression | ||
|---|---|---|---|---|
| P value | HR (95% CI) | P value | HR (95% CI) | |
| Age (years) | <0.001 | 1.036 (1.019–1.053) | 0.007 | 1.027 (1.007–1.048) |
| BMI | 0.905 | 1.002 (0.968–1.038) | Not included in model | |
| Indication for OLT | ||||
| Ethyl-tox/crypt. Cirrhosis (Ref.) | Reference | Reference | ||
| HBV-/HCV-related cirrhosis | 0.152 | 0.682 (0.404–1.151) | 0.127 | 0.653 (0.378–1.128) |
| HCC/NEC-metastases | 0.011 | 0.576 (0.376–0.882) | 0.005 | 0.533 (0.342–0.830) |
| PSC/PBC | <0.001 | 0.324 (0.188–0.559) | 0.007 | 0.457 (0.258–0.809) |
| (Sub-)Acute liver failure | 0.001 | 0.331 (0.170–0.644) | 0.003 | 0.331 (0.158–0.690) |
| Others | <0.001 | 0.384 (0.227–0.650) | 0.010 | 0.463 (0.259–0.829) |
| Laboratory MELD | 0.615 | 1.004 (0.987–1.022) | Not included in model | |
| Encephalopathy (yes) | 0.318 | 1.196 (0.842–1.697) | ||
| Hemodialysis pre-OLT (yes) | 0.040 | 1.609 (1.022–2.533) | ||
| Respirator treatment pre-OLT (yes) | 0.084 | 1.719 (0.929–3.179) | ||
| Age (years) | 0.056 | 1.011 (1.000–1.023) | ||
| BMI | 0.607 | 0.992 (0.963–1.023) | ||
| IDDM/NIDDM (Ref. none) | 0.329 | 0.783 (0.479–1.280) | ||
| Insulin treatment (Ref. none) | 0.358 | 1.944 (0.471–8.022) | ||
| ICU-stay (days) | 0.085 | 1.031 (0.996–1.067) | ||
| AST (U/L) | 0.737 | 1.000 (0.999–1.001) | ||
| Steatosis in graft (Ref. none) | <0.001 | 1.749 (1.278–2.393) | 0.041 | 1.427 (1.000–2.007) |
| CIT (min) | 0.189 | 1.001 (1.000–1.001) | Not included in model | |
| Duration of surgery | 0.121 | 1.002 (0.999–1.005) | ||
| Primary abdominal closure (yes) | 0.002 | 1.732 (1.218–2.464) | 0.050 | 1.475 (1.000–2.177) |
| Complications graded Dindo ≥3 | <0.001 | 2.311 (1.505–3.549) | 0.001 | 2.187 (1.380–3.465) |
| ICU stay (days) | <0.001 | 1.007 (1.003–1.010) | Not included in model | |
| Hospital stay (days) | 0.035 | 1.004 (1.000–1.007) | ||
| BMI – body mass index; AST – aspartate aminotransferase; OLT – orthotopic liver transplantation; MELD – model for end-stage liver disease; ICU – intensive care unit; CIT – cold ischemia time; HCC/NEC – hepatocellular carcinoma/neuroendocrine; PCS/PBC – primary sclerosing cholangitis/primary biliary cholangitis; IDDM – insulin-dependent diabetes mellitus; NIDDM – non–insulin-dependent diabetes mellitus. | ||||